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The Effect of Olive Leaf Extract on Hepatic Fat Accumulation in Sprague-Dawley Rats Fed a High-fat Diet
http://hdl.handle.net/10069/24159
http://hdl.handle.net/10069/2415982b90ee2-3cbf-4601-8697-50309d2792e7
名前 / ファイル | ライセンス | アクション |
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ActaMed55_29.pdf (518.3 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2010-10-08 | |||||
タイトル | ||||||
タイトル | The Effect of Olive Leaf Extract on Hepatic Fat Accumulation in Sprague-Dawley Rats Fed a High-fat Diet | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Non-alcoholic fatty liver disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Olive leaf extract | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Oleuropein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | High-fat diet | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sprague-Dawley (SD) rats | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Omagari, Katsuhisa
× Omagari, Katsuhisa× Kato, Shigeko× Tsuneyama, Koichi× Hatta, Hideki× Ichimura, Mayuko× Urata, Chisato× Sumiyama, Yasuko× Nishizaki, Ayako× Hashimoto, Sakiko× Harada, Mai× Tamaru, Shizuka× Tanaka, Kazunari |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Oleuropein, the active constituent of olive leaf extract, possesses anti-oxidant, hypoglycemic, and hypolipidemic activities. We aimed to assess whether the effect of olive leaf extract on hepatic fat accumulation is preventive or therapeutic. Sprague-Dawley (SD) rats were fed a high-fat diet with (ODOD group) or without (HDHD group) olive leaf extract (1,000 mg/kg diet) for 38 weeks. Another group of rats were fed a high-fat diet for 23 weeks, followed by a high-fat diet with olive leaf extract (1,000 mg/kg diet) for 15 weeks (HDOD group). Serology, histopathology, anti-oxidative activity, and liver fatty acid synthesis were compared to those fed a standard diet (LDLD group) at 26 and 41 weeks of age. The serum levels of total cholesterol, triglyceride and aspartate aminotransferase tended to be lower in the ODOD group as compared to the HDHD and HDOD groups, although there were no significant differences. Histopathologically, hepatic steatosis tended to be less evident in the HDOD and ODOD groups as compared to the HDHD group, and lobular inflammation was not observed in the ODOD group at 26 weeks of age. Hepatic thioredoxin-1 staining tended to be less evident in the ODOD group than in the HDHD and HDOD groups at 41 weeks of age. There were no significant differences in hepatic lipogenic enzyme activities between the ODOD group and HDHD/HDOD groups. Our data suggest that olive leaf extract had a preventive, rather than therapeutic, effect on hepatic steatohepatitis in SD rats fed a high-fat diet. | |||||
書誌情報 |
Acta Medica Nagasakiensia 巻 55, 号 1, p. 29-30, 発行日 2010-08 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Nagasaki University School of Medicine | |||||
出版者別言語 | ||||||
長崎大学医学部 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta Medica Nagasakiensia, 55(1), pp.29-39; 2010 |