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Evaluation of the potential biological toxicities of aqueous extracts from red tide phytoplankton cultures in in vitro and in vivo systems
http://hdl.handle.net/10069/24231
http://hdl.handle.net/10069/24231d6eb4ea8-8545-4e7c-83b5-eccb684a839d
名前 / ファイル | ライセンス | アクション |
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JTS35_591.pdf (1.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-10-15 | |||||
タイトル | ||||||
タイトル | Evaluation of the potential biological toxicities of aqueous extracts from red tide phytoplankton cultures in in vitro and in vivo systems | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Alexandrium affine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chattonella ovata | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gymnodinium impudicum | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Radical scavenger | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Red tide phytoplankton | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Toxicity | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kim, Daekyung
× Kim, Daekyung× Cha, Seon-Heui× Sato, Emiko× Niwano, Yoshimi× Kohno, Masahiro× Jiang, Zedong× Yamasaki, Yasuhiro× Matsuyama, Yukihiko× Yamaguchi, Kenichi× Oda, Tatsuya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The biological toxic potentials of aqueous extracts from the dinophycean flagellates Gymnodinium impudicum and Alexandrium affine and the raphidophycean flagellate Chattonella ovata were examined in both in vitro and in vivo systems. Interestingly, the extract from A. affine was the only one that showed potent cytotoxicities towards HeLa, Vero, and Neuro-2a cells in a concentration- dependent manner. Mice given intraperitoneal injections of the extracts revealed that none of the extracts exhibited serious toxicities in mice. However, temporal body weight loss was observed in the mice injected with the extract from A. affine during the early stage, and the dramatic enlargement of spleens was also observed in the mice on the 7th day after injection. Since A. affine extract showed potent hemolytic activity in vitro towards mouse erythrocytes, hemolytic anemia may be a possible mechanism responsible for the splenomegaly in the mice injected with A. affine extract. Similar marginal effects were observed in the mice injected with the extract from C. ovata; however, no significant toxic or detrimental effects were detected in the mice injected with the extract from G. impudicum. These results suggest that the extract from G. impudicum may not be contaminated with detectable levels of biologically hazardous compounds and may be relatively safe compared with the other two extracts. | |||||
書誌情報 |
The Journal of Toxicological Sciences 巻 35, 号 4, p. 591-599, 発行日 2010-08 |
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出版者 | ||||||
出版者 | The Japanese Society of Toxicology | |||||
出版者別言語 | ||||||
日本トキシコロジー学会 | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03881350 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00002808 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2131/jts.35.591 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2010 The Japanese Society of Toxicology | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Journal of Toxicological Sciences, 35(4), pp.591-599; 2010 |