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FoxO1 is involved in the antineoplastic effect of calorie restriction.
http://hdl.handle.net/10069/25395
http://hdl.handle.net/10069/253952afed1e6-7a65-4e1a-9d6f-c5cba78fb546
名前 / ファイル | ライセンス | アクション |
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AgiCel9_372.pdf (3.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-07-25 | |||||
タイトル | ||||||
タイトル | FoxO1 is involved in the antineoplastic effect of calorie restriction. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Calorie restriction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | FoxO | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | oxidative stress | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | p21 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tumorigenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lifespan | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamaza, Haruyoshi
× Yamaza, Haruyoshi× Komatsu, Toshimitsu× Wakita, Saori× Kijogi, Carole× Park, Seongjoon× Hayashi, Hiroko× Chiba, Takuya× Mori, Ryoichi× Furuyama, Tatsuo× Mori, Nozomu× Shimokawa, Isao |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The FoxO transcription factors may be involved in the antiaging effect of calorie restriction (CR) in mammals. To test the hypothesis, we used FoxO1 knockout heterozygotic (HT) mice, in which the FoxO1 mRNA level was reduced by 50%, or less, of that in wild-type (WT) mouse tissues. The WT and HT mice were fed ad libitum (AL) or 30% CR diets from 12 weeks of age. Aging- and CR-related changes in body weight, food intake, blood glucose, and insulin concentrations were similar between the WT and HT mice in the lifespan study. The response to oxidative stress, induced by intraperitoneal injection of 3-nitropropionic acid (3-NPA), was evaluated in the liver and hippocampus at 6 months of age. Several of the selected FoxO1-target genes for cell cycle arrest, DNA repair, apoptosis, and stress resistance were up-regulated in the WT-CR tissues after 3-NPA injection, while the effect was mostly diminished in the HT-CR tissues. Of these gene products, we focused on the nuclear p21 protein level in the liver and confirmed its up-regulation only in the WT-CR mice in response to oxidative stress. The lifespan did not differ significantly between the WT and HT mice in AL or CR conditions. However, the antineoplastic effect of CR, as indicated by reduced incidence of tumors at death in the WT-CR mice, was mostly abrogated in the HT-CR mice. The present results suggest a role for FoxO1 in the antineoplastic effect of CR through the induction of genes responsible for protection against oxidative and genotoxic stress. | |||||
書誌情報 |
Aging cell 巻 9, 号 3, p. 372-382, 発行日 2010-06 |
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出版者 | ||||||
出版者 | Blackwell Publishing Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14749726 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12097741 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 20222901 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/j.1474-9726.2010.00563.x | |||||
権利 | ||||||
権利情報 | © 2010 The Authors. Journal compilation © Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 2010 | |||||
権利 | ||||||
権利情報 | The definitive version is available at wileyonlinelibrary.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Aging cell, 9(3), pp.372-382; 2010 |