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Evaluation of miR-122 to Predict High Dose Acetaminophen-Induced Liver Injury in Mice: The Combination Uses of 5-Fluorouracil
http://hdl.handle.net/10069/38700
http://hdl.handle.net/10069/38700ba98eb73-75a1-4247-8150-c5fbc7fe222d
名前 / ファイル | ライセンス | アクション |
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BPBul41_1732.pdf (476.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-11-20 | |||||
タイトル | ||||||
タイトル | Evaluation of miR-122 to Predict High Dose Acetaminophen-Induced Liver Injury in Mice: The Combination Uses of 5-Fluorouracil | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Acetaminophen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Biomarker | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Liver injury | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Micro RNA-122 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Munakata, Chie
× Munakata, Chie× Fuchigami, Yuki× Hiroishi, Shu× Haraguchi, Ayana× Hagimori, Masayori× Enomoto, Hatsune× Tachiki, Hidehisa× Kodama, Yukinobu× Sasaki, Hitoshi× Kawakami, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Administration of high doses of acetaminophen (APAP) is known to cause drug-induced liver injury (DILI) in humans. Therefore, the detection or prediction of these side-effects at an early stage using appropriate biomarkers is the need of the hour. Micro RNA (miR)-122 is expected to be a novel biomarker for liver injury. However, more evidence is required in various alternate situations such as its use in combination as APAP is often used along with anticancer drugs. In the present study, we aimed to evaluate the functions of miR-122 as a biomarker for liver injury in comparison with alanine aminotransferase (ALT) in a mice model with the APAP-induced liver injury (AILI). Consequently, there was a dose-dependent increase in miR-122 after administration of APAP intraperitoneally. Similar observations were made for ALT activity. Additionally, the expression of miR-122 increased in a more rapid manner compared to ALT activity. However, there was a variation in the miR-122 expression. Further, we investigated the drug-drug interaction between APAP and 5-fluorouracil using miR-122 and ALT in mice. As a result, the degree of AILI was not changed by the use of 5-fluorouracil in combination with APAP in mice. | |||||
書誌情報 |
Biological and Pharmaceutical Bulletin 巻 41, 号 11, p. 1732-1735, 発行日 2018-11-01 |
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出版者 | ||||||
出版者 | 日本薬学会 | |||||
出版者別言語 | ||||||
Pharmaceutical Society of Japan | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09186158 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475215 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.b18-00504 | |||||
権利 | ||||||
権利情報 | c 2018 The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biological & pharmaceutical bulletin, 41(11), pp.1732-1735; 2018 |