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Lack of Grafted Liver Rejuvenation in Adult-to-Pediatric Liver Transplantation.
http://hdl.handle.net/10069/24461
http://hdl.handle.net/10069/244611693d3c5-70af-497a-b7a3-e44772c02dbb
名前 / ファイル | ライセンス | アクション |
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DDS56_1542.pdf (4.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-11-08 | |||||
タイトル | ||||||
タイトル | Lack of Grafted Liver Rejuvenation in Adult-to-Pediatric Liver Transplantation. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Graft | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Living donor liver transplantation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pediatric | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rejuvenation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Senescence marker protein-30 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Eguchi, Susumu
× Eguchi, Susumu× Takatsuki, Mitsuhisa× Hidaka, Masaaki× Soyama, Akihiko× Muraoka, Izumi× Tomonaga, Tetsuo× Shimokawa, Isao× Kanematsu, Takashi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: A grafted donor liver should grow and survive under the different conditions presented by a liver transplantation recipient. It has remained unclear, however, whether the age of a grafted liver can be modulated by recipient factors. AIMS: This study investigated whether a grafted aged donor liver can be rejuvenated in a pediatric recipient. METHODS: Of 119 living donor liver transplants, ten pairs were adult-to-pediatric combinations. Senescence marker protein-30 (SMP-30), which is a protein that is remarkably reduced upon aging, was used as a senescence marker. Immunohistochemical staining for SMP-30 was performed in biopsy specimen after living donor liver transplantation (LDLT). Re-expression of SMP-30 was investigated in a biopsied adult liver (n = 6) that had been transplanted in a pediatric recipient. RESULTS: A remarkable expression of SMP-30 was seen in a control pediatric normal liver in comparison with that in an aged adult donor biopsy. Re-expression or an increase in SMP-30 was not observed in the liver of any pediatric recipient who had received an adult liver. CONCLUSION: An adult grafted liver does not appear to rejuvenate in a pediatric recipient. | |||||
書誌情報 |
Digestive diseases and sciences 巻 56, 号 5, p. 1542-1547, 発行日 2011-05 |
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出版者 | ||||||
出版者 | Springer | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01632116 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15732568 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00161107 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 20936349 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s10620-010-1445-5 | |||||
権利 | ||||||
権利情報 | © Springer Science+Business Media, LLC 2010 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Digestive diseases and sciences, 56(5), pp.1542-1547; 2011 |