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In vivo efficacy of doripenem (DRPM) against Pseudomonas aeruginosa in murine chronic respiratory tract infection model.
http://hdl.handle.net/10069/27410
http://hdl.handle.net/10069/2741099fedac2-ec16-4c04-9006-bbb5ecc9a709
名前 / ファイル | ライセンス | アクション |
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JIC17_318.pdf (269.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-07-01 | |||||
タイトル | ||||||
タイトル | In vivo efficacy of doripenem (DRPM) against Pseudomonas aeruginosa in murine chronic respiratory tract infection model. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Carbapenem | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chronic respiratory infection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Doripenem | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lung | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mouse model | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pseudomonas aeruginosa | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Araki, Nobuko
× Araki, Nobuko× Yanagihara, Katsunori× Morinaga, Yoshitomo× Yamada, Koichi× Yamada, Yasuaki× Kohno, Shigeru× Kamihira, Shimeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Doripenem is a carbapenem antibiotic with broad-spectrum coverage of gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa, and is considered to be as effective as meropenem. The in vivo activity of doripenem was thus compared with that of meropenem in a chronic lower respiratory P. aeruginosa infection mouse model. The number of viable bacteria in the lungs of mice after treatment with doripenem, meropenem, and saline was 2.01 ± 0.69, 2.03 ± 0.48, and 3.90 ± 1.40 log(10) CFU/lung, respectively. The number of viable bacteria in the lungs of mice treated with doripenem and meropenem was significantly lower than that in lungs of controls. Histopathological examination of lung specimens from the control group revealed promotion of the inflammatory response in chronic bronchial infection. However, the groups treated with doripenem and meropenem showed weaker inflammatory responses. These results suggest that doripenem treatment is effective against chronic airway infection with P. aeruginosa. | |||||
書誌情報 |
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 巻 17, 号 3, p. 318-321, 発行日 2011-06 |
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出版者 | ||||||
出版者 | Springer | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1341321X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14377780 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11057978 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 20972597 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s10156-010-0166-1 | |||||
権利 | ||||||
権利情報 | © Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases 2010 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of infection and chemotherapy, 17(3), pp.318-321; 2011 |