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Differences in the humoral autoreactivity to zinc transporter 8 between childhood- and adult-onset type 1 diabetes in Japanese patients.
http://hdl.handle.net/10069/24533
http://hdl.handle.net/10069/245337d43658a-5e96-4e59-b407-5b4ebcef766b
名前 / ファイル | ライセンス | アクション |
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CliImm138_146.pdf (178.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-12-14 | |||||
タイトル | ||||||
タイトル | Differences in the humoral autoreactivity to zinc transporter 8 between childhood- and adult-onset type 1 diabetes in Japanese patients. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Autoantibodies | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Epitope | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fulminant | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HLA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Type 1 diabetes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Zinc transporter-8 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kawasaki, Eiji
× Kawasaki, Eiji× Nakamura, Kan× Kuriya, Genpei× Satoh, Tsuyoshi× Kobayashi, Masakazu× Kuwahara, Hironaga× Abiru, Norio× Yamasaki, Hironori× Matsuura, Nobuo× Miura, Junnosuke× Uchigata, Yasuko× Eguchi, Katsumi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The aim of this study was to evaluate the humoral autoreactivity to zinc transporter 8 (ZnT8) depending on the clinical phenotype of type 1 diabetes (T1D). ZnT8 autoantibodies (ZnT8A) were determined by radioimmunoassay using carboxy-terminal ZnT8 constructs in 57 childhood-onset, 97 adult-onset, and 85 fulminant T1D. The ZnT8A frequency was higher in childhood-onset patients and decreased with increasing age of onset from 70% to 24% (P(trend)<0.005). None of the patients with fulminant T1D was positive for ZnT8A. There were at least two distinct ZnT8A epitope patterns associated with the aa325-restriction, childhood-onset patients have aa325-nonrestricted response more frequently compared to the adult-onset group (P<0.05). The level of ZnT8A was inversely associated with the copy number of HLA-DR4 allele (P<0.05). These results suggest differences in the humoral autoreactivity to ZnT8 depending on the clinical phenotype, which should provide strategy for autoantibody measurement in subjects to allow early diagnosis of autoimmune T1D. | |||||
書誌情報 |
Clinical immunology (Orlando, Fla.) 巻 138, 号 2, p. 146-153, 発行日 2011-02 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15216616 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15217035 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA1154463X | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21067978 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.clim.2010.10.007 | |||||
権利 | ||||||
権利情報 | © 2010 Elsevier Inc. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Clinical immunology, 138(2), pp.146-153; 2011 |