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Dexamethasone-induced plasminogen activator inhibitor-1 expression in human primary bone marrow adipocytes
http://hdl.handle.net/10069/24560
http://hdl.handle.net/10069/2456061ed7c89-d2e8-42a9-b62b-49d93d4dfc69
名前 / ファイル | ライセンス | アクション |
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BioRes31_281.pdf (2.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-01-14 | |||||
タイトル | ||||||
タイトル | Dexamethasone-induced plasminogen activator inhibitor-1 expression in human primary bone marrow adipocytes | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hozumi, Akira
× Hozumi, Akira× Osaki, Makoto× Sakamoto, Kazutaka× Goto, Hisataka× Fukushima, Tatsuya× Baba, Hideo× Shindo, Hiroyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Several studies have demonstrated the association of plasminogen activator inhibitor-1 (PAI-1) with osteonecrosis, but the underlying mechanism of osteonecrosis and its relationship with local PAI-1 is not clear. The objective of this study was to evaluate PAI-1 production by primary human bone marrow adipocytes and the effects of glucocorticoid administration. Bone marrow was obtained from 25 individuals during prosthetic insertion. Mature adipocytes were cultured for 24 h with or without dexamethasone. PAI-1, adiponectin, tumor necrosing factor-α (TNFα) expression were measured by latex photometric immunoassay or RT-PCR. Adiponectin, TNFα and PAI-1 were detected in all culture media. PAI-1 expression was signiicantly increased by treatment with 10-6 mol/L dexamethasone up to 24 h in protein and mRNA levels, while the levels of other adipokines did not change by dexamethasone. These results suggest that bone marrow adipocytes may play important roles for the development of glucocorticoid-induced osteonecrotic diseases by enhancing PAI-1 expression. | |||||
書誌情報 |
Biomedical Research 巻 31, 号 5, p. 281-286, 発行日 2010 |
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出版者 | ||||||
出版者 | Biomedical Research Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03886107 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1880313X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00110128 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2220/biomedres.31.281 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2010 Biomedical Research Press | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biomedical Research, 31(5), pp.281-286; 2010 |