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Induction of Late-onset Spontaneous Autoimmune Thyroiditis by a Single Low-dose Irradiation in Thyroiditis-prone Non-obese Diabetic-H2h4 Mice
http://hdl.handle.net/10069/24586
http://hdl.handle.net/10069/245860ba8e5f3-6780-4253-9290-1dc6d2f76ac1
名前 / ファイル | ライセンス | アクション |
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JRR50_573.pdf (94.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-01-26 | |||||
タイトル | ||||||
タイトル | Induction of Late-onset Spontaneous Autoimmune Thyroiditis by a Single Low-dose Irradiation in Thyroiditis-prone Non-obese Diabetic-H2h4 Mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Autoimmune thyroiditis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Iodine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Low-dose irradiation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | NOD-H2 h4 mice | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nagayama, Yuji
× Nagayama, Yuji× Ichikawa, Tatsuki× Saitoh, Ohki× Abiru, Norio |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The previous data regarding the effect of irradiation on thyroid autoimmunity are controversial. We have recently reported the exacerbation of autoimmune thyroiditis by a single low dose (0.5 Gy) of whole body irradiation in thyroiditis-prone non-obese diabetic (NOD)-H2h4 mice treated with iodine for 8 weeks. However, it is uncertain in that report whether the results obtained by the provision of iodine in a relatively short period of time (8 weeks) accurately reflects the long-term consequences of low-dose irradiation on thyroid autoimmunity. Therefore, we repeated these experiments with mice that were monitored after irradiation without iodine treatment for up to 15 months. We found that a single low-dose (0.5 Gy) irradiation increased the incidence and severity of thyroiditis and the incidence and titers of anti-thyroglobulin autoantibodies at 15 months of age. The numbers of splenocytes and percentages of various lymphocyte subsets were not affected by irradiation. Thus, we conclude that low-dose irradiation also exacerbates late-onset spontaneous thyroiditis in NOD-H2h4 mice; one plausible explanation for this may be the acceleration of immunological aging by irradiation. | |||||
書誌情報 |
Journal of Radiation Research 巻 50, 号 6, p. 573-577, 発行日 2009-11-16 |
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出版者 | ||||||
出版者 | 日本放射線影響学会 | |||||
出版者別言語 | ||||||
The Japan Radiation Research Society | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 04493060 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13499157 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00705792 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1269/jrr.09067 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2009 by THE JAPAN RADIATION RESEARCH SOCIETY | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of radiation research, 50(6), pp.573-577; 2009 |