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Introduction of a Normal Human Chromosome 8 Corrects Abnormal Phenotypes of Werner Syndrome Cells Immortalized by Expressing an hTERT Gene
http://hdl.handle.net/10069/24587
http://hdl.handle.net/10069/24587ce810c5e-cb1f-451c-ac0e-a0e5982f9cca
名前 / ファイル | ライセンス | アクション |
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JRR50_253.pdf (567.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-01-27 | |||||
タイトル | ||||||
タイトル | Introduction of a Normal Human Chromosome 8 Corrects Abnormal Phenotypes of Werner Syndrome Cells Immortalized by Expressing an hTERT Gene | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Werner syndrome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chromosome transfer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Functional complementation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ariyoshi, Kentaro
× Ariyoshi, Kentaro× Suzuki, Keiji× Goto, Makoto× Oshimura, Mitsuo× Ishizaki, Kanji× Watanabe, Masami× Kodama, Seiji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Werner syndrome (WS) is an autosomal recessive disease characterized by premature aging and caused by mutations of the WRN gene mapped at 8p12. To examine functional complementation of WS phenotypes, we introduced a normal human chromosome 8 into a strain of WS fibroblasts (WS3RGB) immortalized by expressing a human telomerase reverse transcriptase subunit (hTERT) gene. Here, we demonstrate that the abnormal WS phenotypes including cellular sensitivities to 4-nitroquinoline-1-oxide (4NQO) and hydroxy urea (HU), and chromosomal radiosensitivity at G2 phase are corrected by expression of the WRN gene mediated by introducing a chromosome 8. This indicates that those multiple abnormal WS phenotypes are derived from a primary, but not secondary, defect in the WRN gene. | |||||
書誌情報 |
Journal of Radiation Research 巻 50, 号 3, p. 253-259, 発行日 2009-05-16 |
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出版者 | ||||||
出版者 | 日本放射線影響学会 | |||||
出版者別言語 | ||||||
The Japan Radiation Research Society | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 04493060 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13499157 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00705792 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1269/jrr.08111 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2009 by THE JAPAN RADIATION RESEARCH SOCIETY | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of radiation research, 50(3), pp.253-259; 2009 |