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The clinical differences between young-onset FMF (YOFMF), adult-onset FMF(AOFMF), and late-onset FMF(LOFMF)in Japan are unclear. METHODS: We enrolled 395 consecutive patients. We defined YOFMF, AOFMF, and LOFMF as the onset of FMF at\u003c20, 20-39, and??40years of age, respectively. We compared clinical manifestations and MEFV mutations patterns among these groups. RESULTS: Median ages at onset were YOFMF 12.5 years (n?=?182), AOFMF 28 years (n?=?115), and LOFMF 51years (n?=?90). A family history, MEFV mutations in exon 10, and more than two MEFV mutations were significantly more frequent in the earlier-onset groups (p?\u003c?0.01, p?\u003c?0.0001, and p\u003c0.001,respectively). In the accompanying manifestations, thoracic and abdominal pain were significantly more frequent in the earlier-onset groups (p\u003c?0.01and p\u003c0.0001, respectively), whereas arthritis and myalgia were significantly more frequent in the later-onset groups (p\u003c0.0001 and p\u003c?0.01, respectively). The multiple logistic regression analysis revealed that the presence of MEFV exon 10mutations and earlier onset were significantly associated with serositis, whereas the absence of MEFV exon 10mutations, later onset, and the presence of erysipelas-like erythema were significantly associated with musculoskeletal manifestations. There was no significant between-group difference in the responsiveness to colchicine. CONCLUSIONS: Our results indicate that the later-onset FMF patients had a lower percentage of MEFV mutations in exon 10 and predominantly presented arthritis and myalgia. 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Musculoskeletal manifestations occur predominantly in patients with later-onset familial Mediterranean fever: Data from a multicenter, prospective national cohort study in Japan
http://hdl.handle.net/10069/38725
http://hdl.handle.net/10069/38725a9e10d3a-156b-49bd-bcfc-3ecf8a73172a
名前 / ファイル | ライセンス | アクション |
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ART20_257.pdf (639.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-12-05 | |||||
タイトル | ||||||
タイトル | Musculoskeletal manifestations occur predominantly in patients with later-onset familial Mediterranean fever: Data from a multicenter, prospective national cohort study in Japan | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Familial Mediterranean fever | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Late onset | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MEFV gene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Musculoskeletal manifestations | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Young onset | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Endo, Yushiro
× Endo, Yushiro× Koga, Tomohiro× Ishida, Midori× Fujita, Yuya× Tsuji, Sosuke× Takatani, Ayuko× Shimizu, Toshimasa× Sumiyoshi, Remi× Igawa, Takashi× Umeda, Masataka× Fukui, Shoichi× Nishino, Ayako× Kawashiri, Shin-ya× Iwamoto, Naoki× Ichinose, Kunihiro× Tamai, Mami× Nakamura, Hideki× Origuchi, Tomoki× Agematsu, Kazunaga× Yachie, Akihiro× Masumoto, Junya× Migita, Kiyoshi× Kawakami, Atsushi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: We showed previously that Japanese individuals with familial Mediterranean fever (FMF) have a more atypical phenotype compared to endemic areas. The clinical differences between young-onset FMF (YOFMF), adult-onset FMF(AOFMF), and late-onset FMF(LOFMF)in Japan are unclear. METHODS: We enrolled 395 consecutive patients. We defined YOFMF, AOFMF, and LOFMF as the onset of FMF at<20, 20-39, and??40years of age, respectively. We compared clinical manifestations and MEFV mutations patterns among these groups. RESULTS: Median ages at onset were YOFMF 12.5 years (n?=?182), AOFMF 28 years (n?=?115), and LOFMF 51years (n?=?90). A family history, MEFV mutations in exon 10, and more than two MEFV mutations were significantly more frequent in the earlier-onset groups (p?<?0.01, p?<?0.0001, and p<0.001,respectively). In the accompanying manifestations, thoracic and abdominal pain were significantly more frequent in the earlier-onset groups (p<?0.01and p<0.0001, respectively), whereas arthritis and myalgia were significantly more frequent in the later-onset groups (p<0.0001 and p<?0.01, respectively). The multiple logistic regression analysis revealed that the presence of MEFV exon 10mutations and earlier onset were significantly associated with serositis, whereas the absence of MEFV exon 10mutations, later onset, and the presence of erysipelas-like erythema were significantly associated with musculoskeletal manifestations. There was no significant between-group difference in the responsiveness to colchicine. CONCLUSIONS: Our results indicate that the later-onset FMF patients had a lower percentage of MEFV mutations in exon 10 and predominantly presented arthritis and myalgia. It is important to distinguish their FMF from other inflammatory diseases. | |||||
書誌情報 |
Arthritis Research & Therapy 巻 20, 号 1, p. 257, 発行日 2018-11-20 |
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出版者 | ||||||
出版者 | BioMed Central Ltd. | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14786362 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1186/s13075-018-1738-1 | |||||
権利 | ||||||
権利情報 | cThe Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Arthritis Research & Therapy, 20(1), 257; 2018 |