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Development of Calorie Restriction Mimetics as Therapeutics for Obesity, Diabetes, Inflammatory and Neurodegenerative Diseases
http://hdl.handle.net/10069/24614
http://hdl.handle.net/10069/24614fc7ca398-c005-4b36-b7da-9e24673b2761
名前 / ファイル | ライセンス | アクション |
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CurGen11_562.pdf (72.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-02-09 | |||||
タイトル | ||||||
タイトル | Development of Calorie Restriction Mimetics as Therapeutics for Obesity, Diabetes, Inflammatory and Neurodegenerative Diseases | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Biosensing | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Calorie restriction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Drug discovery | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Metabolism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Neurodegeneration | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Chiba, Takuya
× Chiba, Takuya× Tsuchiya, Tomoshi× Komatsu, Toshimitsu× Mori, Ryoichi× Hayashi, Hiroko× Shimokawa, Isao |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Calorie restriction (CR) is the most robust intervention that decreases morbidity and mortality, and thereby increases the lifespan of many organisms. Although the signaling pathways involved in the beneficial effects of CR are not yet fully understood. Several candidate pathways and key molecules have been identified. The effects of CR are highly conserved from lower organisms such as yeast to higher mammals such as rodents and monkeys. Recent studies have also demonstrated beneficial effects of CR in humans, although we need much longer studies to evaluate whether CR also increases the lifespan of humans. In reality, it is difficult for us to conduct CR interventions in humans because the subjects must be kept in a state of hunger and the duration of this state needed to achieve a clinically meaningful effect is still unknown. Thus, research in this field is focusing on the development of molecules that mimic the beneficial effects of CR without reducing food intake. Some of these candidate molecules include plant-derived functional chemicals (phytochemicals), synthetic small molecules, and endocrine molecules such as adipokines. Several studies have already shown that this research field may yield novel drugs for the treatment of age-related diseases such as diabetes. In this article, we describe the target pathways, candidate molecules, and strategies to develop CR mimetics. | |||||
書誌情報 |
Current Genomics 巻 11, 号 8, p. 562-567, 発行日 2010-12-01 |
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出版者 | ||||||
出版者 | Bentham Science Publishers | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13892029 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11629379 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2174/138920210793360934 | |||||
権利 | ||||||
権利情報 | © 2010 Bentham Science Publishers Ltd. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Current Genomics, 11(8), pp.562-567; 2010 |