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LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway.
http://hdl.handle.net/10069/24828
http://hdl.handle.net/10069/24828315ad0fd-5ab1-493e-84e8-0461b16f5014
名前 / ファイル | ライセンス | アクション |
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Leukemia25_575.pdf (880.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-03-30 | |||||
タイトル | ||||||
タイトル | LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hasegawa, H
× Hasegawa, H× Yamada, Yasuaki× Tsukasaki, Katsumi× Mori, N× Tsuruda, Kazuto× Sasaki, Daisuke× Usui, Tetsuya× Osaka, Akemi× Atogami, Sunao× Ishikawa, Chie× Machijima, Yoshiaki× Sawada, S× Hayashi, Tomayoshi× Miyazaki, Yasushi× Kamihira, Shimera |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Adult T-cell leukemia/lymphoma (ATLL), an aggressive neoplasm etiologically associated with human T-lymphotropic virus type-1 (HTLV-1), is resistant to treatment. In this study, we examined the effects of a new inhibitor of deacetylase enzymes, LBH589, on ATLL cells. LBH589 effectively induced apoptosis in ATLL-related cell lines and primary ATLL cells and reduced the size of tumors inoculated in SCID mice. Analyses, including with a DNA microarray, revealed that neither death receptors nor p53 pathways contributed to the apoptosis. Instead, LBH589 activated an intrinsic pathway through the activation of caspase-2. Furthermore, small interfering RNA experiments targeting caspase-2, caspase-9, RAIDD, p53-induced protein with a death domain (PIDD) and RIPK1 (RIP) indicated that activation of RAIDD is crucial and an event initiating this pathway. In addition, LBH589 caused a marked decrease in levels of factors involved in ATLL cell proliferation and invasion such as CCR4, IL-2R and HTLV-1 HBZ-SI, a spliced form of the HTLV-1 basic zipper factor HBZ. In conclusion, we showed that LBH589 is a strong inducer of apoptosis in ATLL cells and uncovered a novel apoptotic pathway initiated by activation of RAIDD.Leukemia advance online publication, 18 January 2011; doi:10.1038/leu.2010.315. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ | |||||
書誌情報 |
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 巻 25, 号 4, p. 575-578, 発行日 2011-04 |
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出版者 | ||||||
出版者 | Nature Publishing Group | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 08876924 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14765551 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10668706 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21242994 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/leu.2010.315 | |||||
権利 | ||||||
権利情報 | © 2011 Macmillan Publishers Limited All rights reserved 0887-6924/11 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Leukemia, 25(4), pp.575-578; 2011 |