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Human papillomavirus infection induces NF-κB activation in cervical cancer: A comparison with penile cancer
http://hdl.handle.net/10069/26619
http://hdl.handle.net/10069/26619fb2bba51-cb06-421c-85c3-14d9e966310e
名前 / ファイル | ライセンス | アクション |
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OncLet2_65.pdf (502.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-12-01 | |||||
タイトル | ||||||
タイトル | Human papillomavirus infection induces NF-κB activation in cervical cancer: A comparison with penile cancer | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cervical cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Human papillomavirus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nuclear factor-κB | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Penile cancer | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Senba, Masachika
× Senba, Masachika× Buziba, Nathan× Mori, Naoki× Fujita, Shuichi× Morimoto, Konosuke× Wada, Akihiro× Toriyama, Kan |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This study aimed to determine the relationship between human papillomavirus (HPV) and nuclear factor-κB (NF-κB) in cervical cancer using 62 tissues of cervical cancer, and to compare the findings to penile cancer. HPV-DNA integration is a crucial factor for malignant transformation in cervical cancer and can be identified using in situ hybridization. Of the 62 cases, HPV infection was detected in 28 (45.2%). This frequency was lower than in penile cancer (68.2%) as shown by our previous study. The earliest age of onset of cervical and penile cancer was 18 and 35, respectively, whereas the mean age of the initial diagnosis of cervical and penile cancer was 50.1 and 59.6, respectively. The discrepancies of HPV prevalence, earliest ages of onset and mean ages between cervical and penile cancer patients may result from the gender-based synergistic action of HPV associated with multiple epidemiological co-factors. Of the 28 HPV-infected cases, NF-κB expression was observed in the nucleus in 18 (64.3%), in the cytoplasm in 19 (67.9%) and in the nucleus and/or cytoplasm in 27 cases (96.4%). The overexpression of NF-κB in cervical cancer cases suggests that NF-κB activation is a key modulator in driving chronic inflammation to cancer. | |||||
書誌情報 |
Oncology Letters 巻 2, 号 1, p. 65-68, 発行日 2010-11-23 |
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出版者 | ||||||
出版者 | Spandidos Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17921074 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3892/ol.2010.207 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Oncology Letters, 2(1), pp.65-68; 2010 |