WEKO3
アイテム
{"_buckets": {"deposit": "e6da3848-3e37-46cd-8e10-f8eb1554b126"}, "_deposit": {"created_by": 2, "id": "14837", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "14837"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00014837", "sets": ["347"]}, "author_link": ["54462", "54467", "54463", "54466", "54458", "54461", "54459", "54464", "54457", "54460", "54465"], "item_3_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "54", "bibliographicPageStart": "47", "bibliographicVolumeNumber": "55", "bibliographic_titles": [{"bibliographic_title": "Acta Medica Nagasakiensia"}]}]}, "item_3_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Although hyperhomocysteinemia is an important and independent risk factor for vascular disease, the relationship between plasma homocysteine concentration (Hcy) and subclinical atherosclerosis in the general population remains controversial. We screened 1,845 participants who resided on Japanese remote islands and in mainland. Hcy and clinical values were measured, and methylenetetrahydrofolate reductase gene C677T polymorphism (C677T/MTHFR), which is an important genetic factor for regulating Hcy, was analyzed. Carotid intima-media thickness (CIMT) and the cardio ankle vascular index (CAVI) were measured to clinically evaluate subclinical atherosclerosis. CAVI had statistically significant association with Hcy (regression coefficient 0.3159, p=0.025), but CIMT was not. Hcy had statistically significant association with age, systolic blood pressure, high-density lipoprotein cholesterol, creatinine, C677T/MTHFR, smoking status and alcohol intake. Although C677T/MTHFR was not different among residing areas, Hcy was significantly higher on small islands than in other areas even after adjustment for confounding factors. We found the statistically significant association between Hcy and CAVI in the general population residing on Japanese remote islands, and significant differences in Hcy among residing areas, suggesting strong influence by acquired factors as well as genetic factors.", "subitem_description_type": "Abstract"}]}, "item_3_description_64": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Acta Medica Nagasakiensia, 55(2), pp.47-54; 2011", "subitem_description_type": "Other"}]}, "item_3_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nagasaki University School of Medicine"}]}, "item_3_relation_42": {"attribute_name": "関係URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://hdl.handle.net/10069/26741"}]}]}, "item_3_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508430", "subitem_source_identifier_type": "NCID"}]}, "item_3_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00016055", "subitem_source_identifier_type": "ISSN"}]}, "item_3_text_62": {"attribute_name": "sortkey", "attribute_value_mlt": [{"subitem_text_value": "1"}]}, "item_3_text_63": {"attribute_name": "出版者別言語", "attribute_value_mlt": [{"subitem_text_value": "長崎大学医学部"}]}, "item_3_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakazato, Mio"}], "nameIdentifiers": [{"nameIdentifier": "54457", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takamura, Noboru"}], "nameIdentifiers": [{"nameIdentifier": "54458", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kadota, Koichiro"}], "nameIdentifiers": [{"nameIdentifier": "54459", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamasaki, Hironori"}], "nameIdentifiers": [{"nameIdentifier": "54460", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mukae, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "54461", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kusano, Yosuke"}], "nameIdentifiers": [{"nameIdentifier": "54462", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakashima, Kenichiro"}], "nameIdentifiers": [{"nameIdentifier": "54463", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ozono, Yoshiyuki"}], "nameIdentifiers": [{"nameIdentifier": "54464", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aoyagi, Kiyoshi"}], "nameIdentifiers": [{"nameIdentifier": "54465", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kohno, Shigeru"}], "nameIdentifiers": [{"nameIdentifier": "54466", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maeda, Takahiro"}], "nameIdentifiers": [{"nameIdentifier": "54467", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ActMed55_47.pdf", "filesize": [{"value": "214.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 214100.0, "url": {"label": "ActMed55_47.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/14837/files/ActMed55_47.pdf"}, "version_id": "c72f91cb-463a-41f4-b515-b2246923b6b4"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Atherosclerosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cardio ankle vascular index", "subitem_subject_scheme": "Other"}, {"subitem_subject": "carotid intima-media thickness", "subitem_subject_scheme": "Other"}, {"subitem_subject": "homocysteine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "methylenetetrahydrofolate reductase gene C677T polymorphism", "subitem_subject_scheme": "Other"}, {"subitem_subject": "remote island", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The association between atherosclerosis and plasma homocysteine concentration in the general population residing on remote islands in Japan", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The association between atherosclerosis and plasma homocysteine concentration in the general population residing on remote islands in Japan"}]}, "item_type_id": "3", "owner": "2", "path": ["347"], "permalink_uri": "http://hdl.handle.net/10069/24842", "pubdate": {"attribute_name": "公開日", "attribute_value": "2011-04-01"}, "publish_date": "2011-04-01", "publish_status": "0", "recid": "14837", "relation": {}, "relation_version_is_last": true, "title": ["The association between atherosclerosis and plasma homocysteine concentration in the general population residing on remote islands in Japan"], "weko_shared_id": 2}
The association between atherosclerosis and plasma homocysteine concentration in the general population residing on remote islands in Japan
http://hdl.handle.net/10069/24842
http://hdl.handle.net/10069/248429a3a29bb-4615-4570-b2a1-b26953fe453a
名前 / ファイル | ライセンス | アクション |
---|---|---|
ActMed55_47.pdf (214.1 kB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2011-04-01 | |||||
タイトル | ||||||
タイトル | The association between atherosclerosis and plasma homocysteine concentration in the general population residing on remote islands in Japan | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Atherosclerosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cardio ankle vascular index | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | carotid intima-media thickness | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | homocysteine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | methylenetetrahydrofolate reductase gene C677T polymorphism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | remote island | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Nakazato, Mio
× Nakazato, Mio× Takamura, Noboru× Kadota, Koichiro× Yamasaki, Hironori× Mukae, Hiroshi× Kusano, Yosuke× Nakashima, Kenichiro× Ozono, Yoshiyuki× Aoyagi, Kiyoshi× Kohno, Shigeru× Maeda, Takahiro |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although hyperhomocysteinemia is an important and independent risk factor for vascular disease, the relationship between plasma homocysteine concentration (Hcy) and subclinical atherosclerosis in the general population remains controversial. We screened 1,845 participants who resided on Japanese remote islands and in mainland. Hcy and clinical values were measured, and methylenetetrahydrofolate reductase gene C677T polymorphism (C677T/MTHFR), which is an important genetic factor for regulating Hcy, was analyzed. Carotid intima-media thickness (CIMT) and the cardio ankle vascular index (CAVI) were measured to clinically evaluate subclinical atherosclerosis. CAVI had statistically significant association with Hcy (regression coefficient 0.3159, p=0.025), but CIMT was not. Hcy had statistically significant association with age, systolic blood pressure, high-density lipoprotein cholesterol, creatinine, C677T/MTHFR, smoking status and alcohol intake. Although C677T/MTHFR was not different among residing areas, Hcy was significantly higher on small islands than in other areas even after adjustment for confounding factors. We found the statistically significant association between Hcy and CAVI in the general population residing on Japanese remote islands, and significant differences in Hcy among residing areas, suggesting strong influence by acquired factors as well as genetic factors. | |||||
書誌情報 |
Acta Medica Nagasakiensia 巻 55, 号 2, p. 47-54, 発行日 2011-03 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Nagasaki University School of Medicine | |||||
出版者別言語 | ||||||
長崎大学医学部 | ||||||
関係URI | ||||||
関連名称 | http://hdl.handle.net/10069/26741 | |||||
sortkey | ||||||
1 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta Medica Nagasakiensia, 55(2), pp.47-54; 2011 |