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HPLC determination of methylphenidate and its metabolite, ritalinic acid, by high-performance liquid chromatography with peroxyoxalate chemiluminescence detection.
http://hdl.handle.net/10069/25015
http://hdl.handle.net/10069/25015dc827fa8-daef-4885-bc1b-d1287cb5a42a
名前 / ファイル | ライセンス | アクション |
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ABC400_387.pdf (317.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-05-06 | |||||
タイトル | ||||||
タイトル | HPLC determination of methylphenidate and its metabolite, ritalinic acid, by high-performance liquid chromatography with peroxyoxalate chemiluminescence detection. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Methylphenidate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ritalinic acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HPLC | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Peroxyoxalate chemiluminescence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 4-(N,N-dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Wada, Mitsuhiro
× Wada, Mitsuhiro× Abe, Keisuke× Ikeda, Rie× Kikura-Hanajiri, Ruri× Kuroda, Naotaka× Nakashima, Kenichiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | An HPLC-peroxyoxalate chemiluminescence (PO-CL) method for simultaneous determination of methylphenidate (MPH) and ritalinic acid (RA) was developed. The method was used to monitor MPH and RA after administration of MPH to rats. Deproteinized plasma spiked with 1-(3-trifluoromethylphenyl)piperazine (IS) was dried and labeled with 4-(N,N-dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole (DBD-F). The labeled sample was cleaned with two kinds of solid-phase extraction cartridge, and the DBD-labels were separated on an ODS column with gradient elution using a mixture of CH(3)CN and imidazole-HNO(3) buffer. Separation of MPH and RA can be achieved within 33 min. The LODs of MPH and RA at a signal-to-noise ratio of 3 were 2.2 and 0.4 ng mL(-1), respectively. Moreover, monitoring of MPH and RA after MPH administration (10 mg kg(-1)) to rat could be performed. The concentration of RA 480 min after administration was eight times higher than that of MPH. The proposed HPLC-PO-CL method was useful for determination of MPH and RA in rat plasma and was successfully used to monitor these substances after MPH administration. | |||||
書誌情報 |
Analytical and bioanalytical chemistry 巻 400, 号 2, p. 387-393, 発行日 2011-04 |
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出版者 | ||||||
出版者 | Springer Verlag | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 16182642 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 16182650 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11610734 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21318251 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00216-011-4713-0 | |||||
権利 | ||||||
権利情報 | © Springer-Verlag 2011 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Analytical and Bioanalytical Chemistry, 400(2), pp.387-393; 2011 |