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Thyroid Autoimmunity and Thyroid Cancer ? The Pathogenic Connection: A 2018 Update
http://hdl.handle.net/10069/38767
http://hdl.handle.net/10069/38767cd36284d-7e73-4d2c-a74d-c3fd1ab3b0ea
名前 / ファイル | ライセンス | アクション |
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HMR50_922.pdf (534.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-08-06 | |||||
タイトル | ||||||
タイトル | Thyroid Autoimmunity and Thyroid Cancer ? The Pathogenic Connection: A 2018 Update | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | benign nodule | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bias | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | papillary thyroid cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TSH | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nagayama, Yuji
× Nagayama, Yuji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The association between thyroid cancer and thyroid autoimmunity has long been suggested, but remains to be elucidated for several decades. Here the data on this issue are updated by summarizing relevant papers published between 2012 and early 2018. Although numerous papers demonstrated the significant increase in the prevalence of thyroid autoimmunity (positive intrathyroidal lymphocyte infiltration and/or anti-thyroglobulin/thyroid peroxidase antibodies) in patients with thyroid cancers as compared to those with benign nodules, and also the significant increase in the prevalence of papillary thyroid cancer (PTC) in patients with thyroid autoimmunity as compared to those without, there are some crucial biases that should be taken into account for their interpretation.However, a difference in the incidence of thyroid autoimmunity in patients with PTCs and those with other types of thyroid cancers appears to support the significant association of two conditions. Thyroid autoimmunity is, at least partly, likely to be elicited against antigens shared by normal and cancerous thyroid tissues, thereby inducing autoimmunity. At the same time, elevated TSH levels (even within the normal reference ranges), which often accompany Hashimoto's patients are a risk factor for thyroid cancer. However, it is still unclear whether or not the co-existence of thyroid autoimmunity impacts on cancer characteristics and prognosis.This issue needs to be further investigated with large-scale prospective studies. |
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書誌情報 |
Hormone and Metabolic Research 巻 50, 号 12, p. 922-931, 発行日 2018-08-06 |
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出版者 | ||||||
出版者 | Georg Thieme Verlag | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00185043 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14394286 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1055/a-0648-4593 | |||||
権利 | ||||||
権利情報 | c 2018 Georg Thieme Verlag. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Hormone and Metabolic Research, 50(12), pp.922-931; 2018 |