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Suppressive effect of ascophyllan HS on postprandial blood sugar level through the inhibition of α-glucosidase and stimulation of glucagon-like peptide-1 (GLP-1) secretion
http://hdl.handle.net/10069/38768
http://hdl.handle.net/10069/3876809cc848b-6695-4960-ae30-73c154e80f2f
名前 / ファイル | ライセンス | アクション |
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IJBM125_453.pdf (331.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-03-15 | |||||
タイトル | ||||||
タイトル | Suppressive effect of ascophyllan HS on postprandial blood sugar level through the inhibition of α-glucosidase and stimulation of glucagon-like peptide-1 (GLP-1) secretion | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ascophyllum nodosum | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ascophyllan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ascophyllan HS | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | α-glucosidase inhibitor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Secretagogue of GLP-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | anti-diabetic effect | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HbA1c | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Okimura, Takasi
× Okimura, Takasi× Jiang, Zedong× Liang, Yan× Yamaguchi, Kenichi× Oda, Tatsuya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A sulfated polysaccharide ascophyllan inhibited α-glucosidase in a concentration dependent manner, and more than 90% activity was inhibited at 1.0 mg/mL. The inhibitory activity was much higher than that of acarbose.No significant inhibitory effect of ascophyllan on α-amylase was observed up to 10.0 mg/mL. Ascophyllan HS, a commercially available ascophyllan preparation showed even higher inhibitory effect on α-glucosidase than ascophyllan. Interestingly, ascophyllan and ascophyllan HS induced the secretion of glucagon-like peptide-1 (GLP-1) from human intestinal NCI-H716 cell line in a concentration dependent manner (10~100 ng/mL). The oral glucose tolerance tests revealed that after continuous 8-week ingestion of ascophyllan HS at 100 mg/day, the glucose area under the curve values of the ascophyllan HS ingested group were significantly lower than placebo ingested group. Serum glycosylated hemoglobin (HbA1c) level in ascophyllan HS ingested group tended to decrease after 8-week ingestion, whereas no significant change was observed in placebo ingested group. This is the first report indicating that ascophyllan can induce the secretion of GLP-1 from human intestinal cell line (NCI-H716), besides the potent inhibitory effect on α-glucosidase.Furthermore, clinical trial suggested that ascophyllan HS may be a practically applicable blood glucose controlling agent in humans. |
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書誌情報 |
International Journal of Biological Macromolecules 巻 125, p. 453-458, 発行日 2019-03-15 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01418130 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ijbiomac.2018.12.084 | |||||
権利 | ||||||
権利情報 | c2019, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Journal of Biological Macromolecules, 125, pp.453-458; 2019 |