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Methods: This was a clinical observational study of 72 patients with untreated IgG4-RD from four institutions in Japan.The serum concentrations of growth differentiation factor 15 (GDF-15), CCL2, hyaluronic acid (HA), amino-terminal propeptide of type III procollagen (PIIINP), and tissue inhibitor of metalloproteinases 1 (TIMP-1) were measured by enzyme-linked immunosorbent assays. The enhanced liver fibrosis (ELF) score was calculated from the TIMP-1, PIIINP, and HA values. We evaluated associations between the values of these biomarkers and laboratory data, the IgG4-RD responder index (IgG4-RD RI) score, and organ involvements. Results: Compared with the 44 healthy controls, the patients with IgG4-RD showed significantly elevated serum concentrations of GDF-15, MCP-1, HA, PIIINP, \nand TIMP-1 and ELF scores. The patients\u0027 serum concentrations of GDF-15, CCL2, \nHA, and TIMP-1 (but not PIIINP) were positively correlated with each other. 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Association of serum levels of fibrosis-related biomarkers with disease activity in patients with IgG4-related disease
http://hdl.handle.net/10069/38770
http://hdl.handle.net/10069/38770f512cae1-67ab-4c3a-a7df-fd81c11e1eb3
名前 / ファイル | ライセンス | アクション |
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ART20_277.pdf (882.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-01-17 | |||||
タイトル | ||||||
タイトル | Association of serum levels of fibrosis-related biomarkers with disease activity in patients with IgG4-related disease | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IgG4-related disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fibrosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | GDF-15 organ involvement | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prednisolone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Responder index | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kawashiri, Shin-ya
× Kawashiri, Shin-ya× Origuchi, Tomoki× Umeda, Masataka× Nishino, Ayako× Shimizu, Toshimasa× Fukui, Shoichi× Koga, Tomohiro× Iwamoto, Naoki× Ichinose, Kunihiro× Tamai, Mami× Nakamura, Hideki× Maeda, Takahiro× Kawano, Mitsuhiro× Yamamoto, Motohisa× Izumi, Yasumori× Kawakami, Atsushi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: The aim of this study was to identify fibrosis-related serological surrogate outcome measures in patients with immunoglobulin G4-related disease (IgG4-RD). Methods: This was a clinical observational study of 72 patients with untreated IgG4-RD from four institutions in Japan.The serum concentrations of growth differentiation factor 15 (GDF-15), CCL2, hyaluronic acid (HA), amino-terminal propeptide of type III procollagen (PIIINP), and tissue inhibitor of metalloproteinases 1 (TIMP-1) were measured by enzyme-linked immunosorbent assays. The enhanced liver fibrosis (ELF) score was calculated from the TIMP-1, PIIINP, and HA values. We evaluated associations between the values of these biomarkers and laboratory data, the IgG4-RD responder index (IgG4-RD RI) score, and organ involvements. Results: Compared with the 44 healthy controls, the patients with IgG4-RD showed significantly elevated serum concentrations of GDF-15, MCP-1, HA, PIIINP, and TIMP-1 and ELF scores. The patients' serum concentrations of GDF-15, CCL2, HA, and TIMP-1 (but not PIIINP) were positively correlated with each other. Among them, serum GDF-15 most efficiently distinguished patients with IgG4-RD from healthy controls. Serum GDF-15 was not associated with the IgG4-RD RI score or the number of organ involvements but was independently associated with the presence of retroperitoneal fibrosis and with parotid gland involvement. Conclusions: We observed increased serological surrogate outcome measures of fibrosis in IgG4-RD. GDF-15 may precisely reflect the fibrotic degree in patients with IgG4-RD. |
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書誌情報 |
Arthritis Research & Therapy 巻 20, 号 1, p. 277, 発行日 2018-12-14 |
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出版者 | ||||||
出版者 | BioMed Central Ltd. | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14786362 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1186/s13075-018-1777-7 | |||||
権利 | ||||||
権利情報 | cThe Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Arthritis Research and Therapy, 20(1), art.no.277; 2018 |