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The Ubiquitin-Proteasome System Is Indispensable for the Maintenance of Muscle Stem Cells
http://hdl.handle.net/10069/38771
http://hdl.handle.net/10069/38771a872d489-5d98-42d4-9012-d17744b726f7
名前 / ファイル | ライセンス | アクション |
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SCR11_1523.pdf (5.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-01-17 | |||||
タイトル | ||||||
タイトル | The Ubiquitin-Proteasome System Is Indispensable for the Maintenance of Muscle Stem Cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | differentiation defect | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | muscle regeneration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | muscle satellite cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | muscle stem cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | p53 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | proliferation defect | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | proteasome dysfunction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | proteolysis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rpt3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | skeletal muscle | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kitajima, Yasuo
× Kitajima, Yasuo× Suzuki, Naoki× Nunomiya, Aki× Osana, Shion× Yoshioka, Kiyoshi× Tashiro, Yoshitaka× Takahashi, Ryosuke× Ono, Yusuke× Aoki, Masashi× Nagatomi, Ryoichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Adult muscle stem cells (satellite cells) are required for adult skeletal muscle regeneration. A proper balance between quiescence, proliferation, and differentiation is essential for the maintenance of the satellite cell pool and their regenerative function. Although the ubiquitin-proteasome is required for most protein degradation in mammalian cells, how its dysfunction affects tissue stem cells remains unclear. Here, we investigated the function of the proteasome in satellite cells using mice lacking the crucial proteasomal component, Rpt3. Ablation of Rpt3 in satellite cells decreased proteasome activity. Proteasome dysfunction in Rpt3-deficient satellite cells impaired their ability to proliferate, survive and differentiate, resulting in defective muscle regeneration. We found that inactivation of proteasomal activity induced proliferation defects and apoptosis in satellite cells. Mechanistically, insufficient proteasomal activity upregulated the p53 pathway, which caused cell-cycle arrest. Our findings delineate a critical function of the proteasome system in maintaining satellite cells in adult muscle. It is not clear how proteasome insufficiency affects tissue stem cells. Kitajima et al. demonstrate that the proteasome system is indispensable for the maintenance of muscle stem cells. Proteasome dysfunction in Rpt3-deficient satellite cells impairs their ability to proliferate, survive and differentiate, resulting in defective muscle regeneration. |
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書誌情報 |
Stem Cell Reports 巻 11, 号 6, p. 1523-1538, 発行日 2018-12-11 |
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出版者 | ||||||
出版者 | Cell Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 22136711 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.stemcr.2018.10.009 | |||||
権利 | ||||||
権利情報 | c 2018 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Stem cell reports, 11(6), pp.1523-1538; 2018 |