WEKO3
アイテム
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Pleiotropic Actions of Helicobacter pylori Vacuolating Cytotoxin, VacA
http://hdl.handle.net/10069/22954
http://hdl.handle.net/10069/229549f21063a-3a5c-4969-a44c-0d986070b930
名前 / ファイル | ライセンス | アクション |
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TJEM220_3.pdf (2.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-02-23 | |||||
タイトル | ||||||
タイトル | Pleiotropic Actions of Helicobacter pylori Vacuolating Cytotoxin, VacA | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Helicobacter pylori | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | VacA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vacuolating toxin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Isomoto, Hajime
× Isomoto, Hajime× Moss, Joel× Hirayama, Toshiya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Helicobacter pylori produces a vacuolating cytotoxin, VacA, and most virulent H. pylori strains secrete VacA. VacA binds to two types of receptor-like protein tyrosine phosphatase (RPTP), RPTPα and RPTPβ, on the surface of host cells. VacA bound to RPTPβ, relocates and concentrates in lipid rafts in the plasma membrane. VacA causes vacuolization, membrane anion-selective channel and pore formation, and disruption of endosomal and lysosomal activity in host cells. Secreted VacA is processed into p33 and p55 fragments. The p55 domain not only plays a role in binding to target cells but also in the formation of oligomeric structures and anionic membrane channels. Oral administration of VacA to wild-type mice, but not to RPTPβ knockout mice, resulted in gastric ulcers, in agreement with the clinical effect of VacA. VacA with s1/m1 allele has more potent cytotoxic activity in relation to peptic ulcer disease and appears to be associated with human gastric cancer. VacA activates pro-apoptotic Bcl-2 family proteins, and induces apoptosis via a mitochondria-dependent pathway. VacA can disrupt other signal transduction pathways; VacA activates p38 MAPK, enhancing production of IL-8 and PGE 2, and PI3K/Akt, suppressing GSK-3β activity. VacA has immunomodulatory actions on T cells and other immune cells, possibly contributing to the chronic infection seen with this organism. H. pylori virulence factors including VacA and CagA, which is encoded by cytotoxin-associated gene A, along with host genetic and environmental factors, constitute a complex network to regulate chronic gastric injury and inflammation, which is involved in a multistep process leading to gastric carcinogenesis. | |||||
書誌情報 |
The Tohoku Journal of Experimental Medicine 巻 220, 号 1, p. 3-14, 発行日 2010-01 |
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出版者 | ||||||
出版者 | Tohoku University Medical Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00408727 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1349-3329 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00863920 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1620/tjem.220.3 | |||||
権利 | ||||||
権利情報 | © 2010 Tohoku University Medical Press. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Tohoku Journal of Experimental Medicine, 220(1), pp.3-14; 2010 |