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Correlation of Pharmacokinetic Parameters with Serum Vancomycin Concentration in Elderly Patients with Malignancies
http://hdl.handle.net/10069/22957
http://hdl.handle.net/10069/229579458934a-9b81-4b63-9b00-1d0b00d780fc
名前 / ファイル | ライセンス | アクション |
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Yakugaku130_69.pdf (179.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-02-24 | |||||
タイトル | ||||||
タイトル | Correlation of Pharmacokinetic Parameters with Serum Vancomycin Concentration in Elderly Patients with Malignancies | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Elderly patient | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Malignancy; Methicillin- resistant Staphylococcus aureus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Therapeutic drug monitoring | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vancomycin pharmacokinetics | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Sadoh, Shinichi
× Sadoh, Shinichi× Tsuji, Yasuhiro× Tsukamoto, Kazuhiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Vancomycin (VCM) is a glycopeptide antibiotic that is generally used to treat methicillin-resistant Staphylococcus aureus (MRSA). Recently, it has been reported that VCM clearance (CL) is significantly higher in elderly patients and infants and children with malignancies, compared with those without malignancies. We have treated many patients with a variety of malignant tumors in whom serum VCM concentrations were found to be moderately lower during therapeutic drug monitoring (TDM). The aim of this study was to determine whether the presence of malignant tumors influences trough concentrations of VCM and VCM pharmacokinetics in elderly patients during treatment for MRSA infection. Comparison of the clinical characteristics and VCM pharmacokinetic parameters between patients with and without malignancies was undertaken in 49 elderly Japanese patients infected with MRSA. The mean trough concentration of VCM in patients with malignancies was significantly lower than that in patients without malignancies. Our results showed significantly higher values of VCM CL and volume of distribution and a shorter elimination half-life in patients with malignancies. Univariate logistic regression analysis of the pharmacokinetic parameters indicated that VCM CL contributed as a significant factor independent of the relation to malignant tumor. In conclusion, it is suggested that the therapeutic effects and side effects of VCM should be actively monitored using TDM, because concentrations may decrease when CL increases in VCM therapy for elderly patients with malignant tumors. | |||||
書誌情報 |
薬学雑誌 en : Journal of the Pharmaceutical Society of Japan 巻 130, 号 1, p. 69-73, 発行日 2010-01 |
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出版者 | ||||||
出版者 | The Pharmaceutical Society of Japan | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00316903 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1347-5231 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00284903 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/yakushi.130.69 | |||||
権利 | ||||||
権利情報 | © 2010 The Pharmaceutical Society of Japan. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 藥學雜誌, 130(1), pp.69-73; 2010 |