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Cleaved PGAM5 is released from mitochondria depending on proteasome-mediated rupture of the outer mitochondrial membrane during mitophagy
http://hdl.handle.net/10069/38785
http://hdl.handle.net/10069/387857aa3ef31-e82e-499a-b5ab-1620854c6c76
名前 / ファイル | ライセンス | アクション |
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JB165_19.pdf (932.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-09-21 | |||||
タイトル | ||||||
タイトル | Cleaved PGAM5 is released from mitochondria depending on proteasome-mediated rupture of the outer mitochondrial membrane during mitophagy | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mitochondria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mitophagy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Parkin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PGAM5 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Proteasome | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamaguchi, Ayane
× Yamaguchi, Ayane× Ishikawa, Hayate× Furuoka, Mana× Yokozeki, Masashi× Matsuda, Noriyuki× Tanimura, Susumu× Takeda, Kohsuke |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | PGAM5 is a unique type of protein phosphatase that exists in mitochondria. It has been shown to exist in the inner mitochondrial membrane through its transmembrane domain and to be cleaved within the transmembrane domain upon mitochondrial dysfunction. However, its submitochondrial localization remains controversial; many researchers claim that PGAM5 localizes to the outer mitochondrial membrane based on the findings that PGAM5 associates with many cytoplasmic proteins. Here, we found that cleaved PGAM5 was released from mitochondria during mitophagy, a selective form of autophagy specific for mitochondria,and that the release was inhibited by proteasome inhibitors in HeLa cells stably expressing the E3 ubiquitin ligase Parkin.However, treatment of parental HeLa cells lacking Parkin with mitophagy-inducing agents caused PGAM5 cleavage but did not cause its release from mitochondria. Thus, cleaved PGAM5 appears to be released from mitochondria depending on proteasome-mediated rupture of the outer membrane during mitophagy, which has been previously shown to precede autophagy-mediated degradation of whole mitochondria. This study suggests that PGAM5 senses mitochondrial dysfunction in the inner mitochondrial membrane and serves as a signalling intermediate that regulates the cellular response to mitochondrial stress upon its cleavage and release from mitochondria. | |||||
書誌情報 |
The Journal of Biochemistry 巻 165, 号 1, p. 19-25, 発行日 2018-09-21 |
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出版者 | ||||||
出版者 | Oxford University Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0021924X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17562651 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/jb/mvy077 | |||||
権利 | ||||||
権利情報 | c The Author(s) 2018. Published by Oxford University Press on behalf of the Japanese Biochemical Society. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of biochemistry, 165(1), pp.19-25; 2019 |