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Bone marrow stroma cells are susceptible to prion infection.
http://hdl.handle.net/10069/23076
http://hdl.handle.net/10069/230762fea37f7-c92c-49bb-97d1-4ab79f76c2db
名前 / ファイル | ライセンス | アクション |
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BBRC377_957.pdf (6.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-03-23 | |||||
タイトル | ||||||
タイトル | Bone marrow stroma cells are susceptible to prion infection. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bone marrow stromal cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | BSE | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CJD | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MSC | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prion protein | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Takakura, Yuka
× Takakura, Yuka× Yamaguchi, Naohiro× Nakagaki, Takehiro× Satoh, Katsuya× Kira, Jun-ichi× Nishida, Noriyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Abnormal protease-resistant prion protein (PrP-res) is the only surrogate biochemical marker for prion diseases, and a sensitive technique to detect PrP-res in blood or tissues is urgently needed. Primary cultured bone marrow stromal cells (MSCs) expressed PrP and were capable of supporting stable human prion infection. Using a mouse-adapted BSE strain, we demonstrated that PrP-res can be detected in expanded MSCs. We then analyzed the bone marrow cells collected at autopsy from two individuals with sporadic Creutzfeldt-Jakob disease (CJD), and, in both cases, cultured MSCs were positive for PrP-res. These data would suggest that ex vivo MSC expansion accompanied by PrP-res analysis could be a helpful tool in the definitive diagnosis of prion disease at an earlier stage in the disease process than is currently possible, and with considerably less distress to the patient. | |||||
書誌情報 |
Biochemical and biophysical research communications 巻 377, 号 3, p. 957-961, 発行日 2008-12-19 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006291X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10902104 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00564395 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18976632 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.bbrc.2008.10.099 | |||||
権利 | ||||||
権利情報 | Copyright © 2008 Elsevier Inc. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biochemical and biophysical research communications, 377(3), pp.957-961; 2008 |