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Role of the Slt2 mitogen-activated protein kinase pathway in cell wall integrity and virulence in Candida glabrata.
http://hdl.handle.net/10069/25190
http://hdl.handle.net/10069/25190d00afca6-4436-4ded-8936-a0f103a5efeb
名前 / ファイル | ライセンス | アクション |
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FEMS10_343.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-06-06 | |||||
タイトル | ||||||
タイトル | Role of the Slt2 mitogen-activated protein kinase pathway in cell wall integrity and virulence in Candida glabrata. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Candida glabrata | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cell wall integrity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Echinocandin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MAPK pathway | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PH | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | SLT2 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Miyazaki, Taiga
× Miyazaki, Taiga× Inamine, Tatsuo× Yamauchi, Shunsuke× Nagayoshi, Yosuke× Saijo, Tomomi× Izumikawa, Koichi× Seki, Masafumi× Kakeya, Hiroshi× Yamamoto, Yoshihiro× Yanagihara, Katsunori× Miyazaki, Yoshitsugu× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Abstract The Slt2 mitogen-activated protein kinase pathway plays a major role in maintaining fungal cell wall integrity. In this study, we investigated the effects of SLT2 deletion and overexpression on drug susceptibility and virulence in the opportunistic fungal pathogen Candida glabrata. While the Deltaslt2 strain showed decreased tolerance to elevated temperature and cell wall-damaging agents, the SLT2-overexpressing strain exhibited increased tolerance to these stresses. A mutant lacking Rlm1, a transcription factor downstream of Slt2, displayed a cell wall-associated phenotype intermediate to that of the Deltaslt2 strain. When RLM1 was overexpressed, micafungin tolerance was increased in the wild-type strain and partial restoration of the drug tolerance was observed in the Deltaslt2 background. It was also demonstrated that echinocandin-class antifungals were more effective against C. glabrata under acidic conditions or when used concurrently with the chitin synthesis inhibitor nikkomycin Z. Finally, in a mouse model of disseminated candidiasis, the deletion and overexpression of C. glabrata SLT2 resulted in mild decreases and increases, respectively, in the CFUs from murine organs compared with the wild-type strain. These fundamental data will help in further understanding the mechanisms of cell wall stress response in C. glabrata and developing more effective treatments using echinocandin antifungals in clinical settings. | |||||
書誌情報 |
FEMS yeast research 巻 10, 号 3, p. 343-352, 発行日 2010-05 |
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出版者 | ||||||
出版者 | Blackwell Publishing Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15671356 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15671364 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11577311 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 20214686 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/j.1567-1364.2010.00611.x | |||||
権利 | ||||||
権利情報 | © 2010 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved | |||||
権利 | ||||||
権利情報 | The definitive version is available at www.blackwell-synergy.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | FEMS yeast research, 10(3), pp.343-352; 2010 |