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Fatty liver incidence and predictive variables.
http://hdl.handle.net/10069/24544
http://hdl.handle.net/10069/24544124fe2a8-91cf-4815-bcc7-38259c858a86
名前 / ファイル | ライセンス | アクション |
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HypRes33_638.pdf (6.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-01-04 | |||||
タイトル | ||||||
タイトル | Fatty liver incidence and predictive variables. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fatty liver | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hypertriglyceridemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Incidence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Obesity | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tsuneto, Akira
× Tsuneto, Akira× Hida, Ayumi× Sera, Nobuko× Imaizumi, Misa× Ichimaru, Shinichiro× Nakashima, Eiji× Seto, Shinji× Maemura, Koji× Akahoshi, Masazumi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although fatty liver predicts ischemic heart disease, the incidence and predictors of fatty liver need examination. The objective of this study was to determine fatty liver incidence and predictive variables. Using abdominal ultrasonography, we followed biennially through 2007 (mean follow-up, 11.6+/-4.6 years) 1635 Nagasaki atomic bomb survivors (606 men) without fatty liver at baseline (November 1990 through October 1992). We examined potential predictive variables with the Cox proportional hazard model and longitudinal trends with the Wilcoxon rank-sum test. In all, 323 (124 men) new fatty liver cases were diagnosed. The incidence was 19.9/1000 person-years (22.3 for men, 18.6 for women) and peaked in the sixth decade of life. After controlling for age, sex, and smoking and drinking habits, obesity (relative risk (RR), 2.93; 95% confidence interval (CI), 2.33-3.69, P<0.001), low high-density lipoprotein-cholesterol (RR, 1.87; 95% CI, 1.42-2.47; P<0.001), hypertriglyceridemia (RR, 2.49; 95% CI, 1.96-3.15; P<0.001), glucose intolerance (RR, 1.51; 95% CI, 1.09-2.10; P=0.013) and hypertension (RR, 1.63; 95% CI, 1.30-2.04; P<0.001) were predictive of fatty liver. In multivariate analysis including all variables, obesity (RR, 2.55; 95% CI, 1.93-3.38; P<0.001), hypertriglyceridemia (RR, 1.92; 95% CI, 1.41-2.62; P<0.001) and hypertension (RR, 1.31; 95% CI, 1.01-1.71; P=0.046) remained predictive. In fatty liver cases, body mass index and serum triglycerides, but not systolic or diastolic blood pressure, increased significantly and steadily up to the time of the diagnosis. Obesity, hypertriglyceridemia and, to a lesser extent, hypertension might serve as predictive variables for fatty liver. | |||||
書誌情報 |
Hypertension research : official journal of the Japanese Society of Hypertension 巻 33, 号 6, p. 638-643, 発行日 2010-06 |
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出版者 | ||||||
出版者 | Japanese Society of Hypertension | |||||
出版者別言語 | ||||||
日本高血圧学会 | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09169636 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10847079 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 20379184 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/hr.2010.45 | |||||
権利 | ||||||
権利情報 | © 2010 The Japanese Society of Hypertension All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Hypertension research, 33(6), pp.638-643; 2010 |