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Amino Acids and Peptides. XXII. Preparation and Antinociceptive Effect of (D-Ala2)Leu-Enkephalin-Poly(Ethylene Glycol) Hybrid.
http://hdl.handle.net/10069/38836
http://hdl.handle.net/10069/3883696d15cca-cad0-4805-b119-ec71a02d5fe8
名前 / ファイル | ライセンス | アクション |
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BPB17_823.pdf (558.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-02-21 | |||||
タイトル | ||||||
タイトル | Amino Acids and Peptides. XXII. Preparation and Antinociceptive Effect of (D-Ala2)Leu-Enkephalin-Poly(Ethylene Glycol) Hybrid. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | enkephalin hybrid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antinociceptive effect | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | poly (ethylene glycol) hybrid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mouse vas deferens | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
MAEDA, Mitsuko
× MAEDA, Mitsuko× KAWASAKI, Koichi× MAYUMI, Tadanori× TAKAHASHI, Masakatsu× KANETO, Hiroshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The hybrid of poly (ethylene glycol) and [D-Ala2] Leu-enkephalin was prepared by the solution method and its antinociceptive effect and inhibitory effect on the electrically induced contractions of mouse vas deferens were examined. The hybrid was synthesized by the coupling of Boc-Tyr-D-Ala-Gly-Phe-Leu-OH and amino-poly (ethylene glycol), followed by trifluoroacetic acid treatment. The hybrid showed more potent antinociceptive activity in mice and 120 times higher inhibitory activity in mouse vas deferens preparation than intact [D-Ala2] Leu-enkephalin. | |||||
書誌情報 |
Biological & Pharmaceutical Bulletin 巻 17, 号 6, p. 823-825, 発行日 1994-01-15 |
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出版者 | ||||||
出版者 | 日本薬学会 | |||||
出版者別言語 | ||||||
Pharmaceutical Society of Japan | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09186158 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475215 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.17.823 | |||||
権利 | ||||||
権利情報 | c The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biological & Pharmaceutical Bulletin, 17(6), pp.823-825; 1994 |