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Physical Dependence Produced by Dihydroetorphine in Mice.
http://hdl.handle.net/10069/38837
http://hdl.handle.net/10069/38837627720b9-f27f-4f19-b7bc-5f69d7e98e2d
名前 / ファイル | ライセンス | アクション |
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BPB17_1056.pdf (702.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-02-21 | |||||
タイトル | ||||||
タイトル | Physical Dependence Produced by Dihydroetorphine in Mice. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dihydroetorphine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | morphine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | naloxone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | physical dependence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | withdrawal sign | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
TOKUYAMA, Shogo
× TOKUYAMA, Shogo× NAKAMURA, Fumihiro× TAKAHASHI, Masakatsu× KANETO, Hiroshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Using various administration schedules, the physical dependence produced by dihydroetorphine (DHE) was compared with that of morphine in mice. Physical dependence, evaluated by naloxone-precipitated withdrawal signs, did not develop following daily treatment with DHE (10, 20, 100 and 1000μg/kg, i. p. or 30, 100 and 1000 ng/mouse, i. c. v.) for 6d. However, 5 repeated injections of DHE (10μg/kg, i. p.) at 1 or 2 h intervals did produce physical dependence and the dependent state disappeared after 2h. Accordingly, it was demonstrated that a sufficient degree of antinociceptive activity needed to be maintained, longer than several hours, for the development of physical dependence on DHE and that the duration of the dependent state was very short. In the single dose suppression test, a single dose of DHE completely suppressed the natural withdrawal signs that appeared following abstinence in morphine-dependent animals without reappearance of significant withdrawal signs, indicating the suitability of DHE as a substitute for morphine. The characteristic properties of DHE, the extremely potent antinociceptive effect and minimal dependence, indicate the separation of the antinociceptive effect from dependence, and suggest that it may be possible to develop a novel drug which may be safely used in clinical situations. | |||||
書誌情報 |
Biological & Pharmaceutical Bulletin 巻 17, 号 8, p. 1056-1059, 発行日 1994-08-15 |
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出版者 | ||||||
出版者 | 日本薬学会 | |||||
出版者別言語 | ||||||
Pharmaceutical Society of Japan | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09186158 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475215 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.17.1056 | |||||
権利 | ||||||
権利情報 | c The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biological & Pharmaceutical Bulletin, 17(8), pp.1056-1059; 1994 |