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In vitro effect of current antimalarial drugs on the survival of paired Schistosoma mansoni adult worms and their egg production.
http://hdl.handle.net/10069/23612
http://hdl.handle.net/10069/236127083f99e-d415-48b1-a360-e27de1033a74
名前 / ファイル | ライセンス | アクション |
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TMH38_69.pdf (45.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-24 | |||||
タイトル | ||||||
タイトル | In vitro effect of current antimalarial drugs on the survival of paired Schistosoma mansoni adult worms and their egg production. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antischistosomal drugs | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antimalarial drugs | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Schistosoma mansoni | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mefloquine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | quinine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | amodiaquine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | primaquine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chloroquine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pyrimethamine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sulfadiazine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mitsui, Yoshinori
× Mitsui, Yoshinori× Aoki, Yoshiki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Some field trials have already demonstrated the high antischistosomal potential of combination therapies using Artesunate (ART) and current antimalarial drugs (Boulanger et al., 2007; Mohamed et al., 2009; Sissoko et al., 2009). The antischistosomal effects of these drugs are noteworthy, especially when they are used for the treatment of malaria in schistosomiasis endemic areas. However, the antischistosomal effects of Amodiaquine (AQ), Primaquine (PQ), Chloroquine (CQ) and Pyrimethamine (Py) have never been assessed by in vitro incubation. The objective of the present study is to assess the in vitro effects of current antimalarial drugs on the egg productivity of adult worm pairs of S. mansoni and their survival times. The effect of the current antimalarial drugs Mefloquine (MQ), quinine (QN), AQ, PQ, CQ, Sulfadiazine (Sf) and Py on the egg output of adult worm pairs of Schistosoma mansoni and their survival times during in vitro culture were assessed at a concentration of 10 Μg⁄ml. AQ, PQ, CQ and Py significantly inhibited the daily egg output of paired female worms at a concentration of 10 Μg⁄ml during the 1 or 2-day in vitro cultivation. However, QN and Sf did not significantly affect the daily egg output during the 8-day incubation. One-day exposure to MQ killed all paired male and female adult worms. AQ and PQ significantly decreased the survival of both paired male and female worms during the 14-day incubation, but QN, CQ, Py and Sf did not exert any similar effect. The present result is consistent with an assessment of the antischistosomal effects of artemisinin-based combination therapy in malaria and schistosomiasis co-endemic areas. | |||||
書誌情報 |
Tropical Medicine and Health 巻 38, 号 2, p. 69-73, 発行日 2010 |
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出版者 | ||||||
出版者 | Japanese Society of Tropical Medicine | |||||
出版者別言語 | ||||||
日本熱帯医学会 | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13488945 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13494147 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11912846 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2149/tmh.2010-04 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2010 by The Japanese Society of Tropical Medicine | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Tropical Medicine and Health, 38(2), pp.69-73; 2010 |