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虚血ラットにおける尾状核内モノアミンの変動 : In vivo dialysisによる経時的観察
http://hdl.handle.net/10069/23669
http://hdl.handle.net/10069/23669b152d8ee-8bc2-4fc7-846a-f08292f4f012
名前 / ファイル | ライセンス | アクション |
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110002277692.pdf (495.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-27 | |||||
タイトル | ||||||
タイトル | 虚血ラットにおける尾状核内モノアミンの変動 : In vivo dialysisによる経時的観察 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ischemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | monoamine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | caudate nucleus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | liquid chromatography | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
河野, 輝昭
× 河野, 輝昭× 三宅, 仁志× 堤, 圭介× 森, 和夫 |
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著者別名 | ||||||
姓名 | Kawano, Teruaki | |||||
著者別名 | ||||||
姓名 | Miyake, Hitoshi | |||||
著者別名 | ||||||
姓名 | Tsutsumi, Keisuke | |||||
著者別名 | ||||||
姓名 | Mori, Kazuo | |||||
その他のタイトル | ||||||
その他のタイトル | Sequential Changes in Dopamine and Monoamine Metabolites in Ischemic Rat Caudate Nucleus : In Vivo Dialysis coupled with High-performance Liquid Chromatography with Electrochemical Detection | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Dialysis tubing with a 0.2-mm diameter was implanted into the caudate nucleus of spontaneously hypertensive rats. Continuous perfusion with Ringer's solution at a flow rate of 10 μl/min was then initiated. During incomplete cerebral ischemia induced by bilateral common carotid artery occlusion, the perfusate was collected every 20 minutes and analyzed for the content of monoamines and their metabolites. The extracellular content of dopamine was abruptly increased about 4 to 6 minutes after ischemic insult, reached a maximum after about 20 to 40 minutes, and then decreased over 120 minutes. During the same period, 3,4-dihydroxyphenyl acetic acid and 5-hydroxyindole acetic acid were significantly decreased, and 5-hydroxytryptamine was not detected during the ischemic period. The results suggest that the ischemia induced a large increase in extracellular dopamine within the caudate nucleus and that leakage occurred due to the energy failure of cell membranes. This process may be one causal factor in the neuronal damage observed after ischemia. | |||||
書誌情報 |
Neurologia medico-chirurgica 巻 28, 号 3, p. 217-222, 発行日 1988-03-15 |
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出版者 | ||||||
出版者 | 日本脳神経外科学会 | |||||
出版者別言語 | ||||||
The Japan Neurosurgical Society | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 04708105 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00358613 | |||||
権利 | ||||||
権利情報 | 日本脳神経外科学会 | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://ci.nii.ac.jp/naid/110002277692/ | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Neurologia medico-chirurgica, 28(3), pp.217-222; 1988 |