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Amino Acids and Peptides. XIX. Preparation of Enkephalin- Poly(ethylene glycol) Hybrid and Evaluation of Its Analgesic Activity.
http://hdl.handle.net/10069/38843
http://hdl.handle.net/10069/3884391eadd7f-684f-4518-bd1f-8a2e774faf2d
名前 / ファイル | ライセンス | アクション |
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CPB41_2053.pdf (467.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-02-21 | |||||
タイトル | ||||||
タイトル | Amino Acids and Peptides. XIX. Preparation of Enkephalin- Poly(ethylene glycol) Hybrid and Evaluation of Its Analgesic Activity. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | poly(ethylene glycol) hybrid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | enkephalin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | enkephalin hybrid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | opioid | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
KAWASAKI, Koichi
× KAWASAKI, Koichi× MAEDA, Mitsuko× YAMASHIRO, Yuko× MAYUMI, Tadanori× TAKAHASHI, Masakatsu× KANETO, Hiroshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The poly(ethylene glycol) hybrid of Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) was prepared and its analgesic activity was examined. Poly(ethylene glycol) #4000 was converted to amino-poly(ethylene glycol) and coupled with the Nα-protected pentapeptide, followed by trifluoroacetic acid treatment to give the hybrid. The hybrid was soluble in water or various organic solvents. The analgesic activity of Leu-enkephalin was markedly potentiated by hybrid formation with poly(ethylene glycol). | |||||
書誌情報 |
Chemical & Pharmaceutical Bulletin 巻 41, 号 11, p. 2053-2054, 発行日 1993-11-15 |
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出版者 | ||||||
出版者 | 日本薬学会 | |||||
出版者別言語 | ||||||
Pharmaceutical Society of Japan | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00092363 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475223 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00602100 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/cpb.41.2053 | |||||
権利 | ||||||
権利情報 | c The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Chemical & Pharmaceutical Bulletin, 41(11), pp.2053-2054; 1993 |