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ヒト脳腫瘍におけるNa^+-K^+ATPase活性の検討
http://hdl.handle.net/10069/23675
http://hdl.handle.net/10069/23675460a146e-3797-43eb-9e2a-1ab0a7eef582
名前 / ファイル | ライセンス | アクション |
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110002279595.pdf (422.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-27 | |||||
タイトル | ||||||
タイトル | ヒト脳腫瘍におけるNa^+-K^+ATPase活性の検討 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | brain neoplasms | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Na^+-K^+ATPase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | epileptogenesis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
三宅, 仁志
× 三宅, 仁志× 栗原, 正紀× 河野, 輝昭× 森, 和夫 |
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著者別名 | ||||||
姓名 | Miyake, Hitoshi | |||||
著者別名 | ||||||
姓名 | Kurihara, Masaki | |||||
著者別名 | ||||||
姓名 | Kawano, Teruaki | |||||
著者別名 | ||||||
姓名 | Mori, Kazuo | |||||
その他のタイトル | ||||||
その他のタイトル | Na^+-K^+ATPase in Human Brain Tumors | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Na^+-K^+T-stimulated adenosine triphosphatase (Na^+-K^+ATP<ase>) activities were measured in 12 human brain tumors and surrounding tissue (white matter and cortex) by the colorimetric determination of hydrolyzed inorganic phosphorus (Pi) from adenosine triphosphate (ATP). In glioma cases, the brain microvessels, glial component, and neurons were isolated from the cortex by the methods of Brendel, et al., and Nagata, et al. In each sample, Na^+-K^+ATP<ase> activity was measured in the presence of various K^+ ion concentrations. In 8 glioma cases, the lowest value was obtained in the glioblastoma multiforme. Decrease in Na^+-K^+ATPase activity in the tumor or in the surrounding tissue was roughly proportional to the pathological malignancy of the tumor. In 2 cases of glioma with an epileptic focus shown by electroencephalography, activity of the enzyme was decreased in the epileptic cortex. In one case of glioma without epileptic focus, decrease of the enzyme activity was mainly attributed to decrease in the glial component. The kinetic parameters, maximum velocity (Vmax) and activation constant for K^+ (Ka) were also calculated in each sample to determine the effect of the K^+ ion on the Na^+-K^+ATPase activity. Vmax in the tumor region was significantly decreased compared with the surrounding tissue. On the other hand, differences in Ka were not so significant. Disturbed buffering action for the extracellular K^+ ions observed in the glioma group might result in lowered ability to maintain the electrolytic milieu, and might play a, significant role in the development of the epileptic focus. | |||||
書誌情報 |
Neurologia medico-chirurgica 巻 26, 号 2, p. 122-126, 発行日 1986-02-15 |
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出版者 | ||||||
出版者 | 日本脳神経外科学会 | |||||
出版者別言語 | ||||||
The Japan Neurosurgical Society | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 04708105 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00358613 | |||||
権利 | ||||||
権利情報 | 日本脳神経外科学会 | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://ci.nii.ac.jp/naid/110002279595/ | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Neurologia medico-chirurgica, 26(2), pp.122-126; 1986 |