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アイテム
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脳梗塞に関する実験的研究(第7報) : 微小血管への電子顕微鏡的アプローチ
http://hdl.handle.net/10069/23682
http://hdl.handle.net/10069/2368224855ee3-f580-4746-b7a2-fd8de1c5a984
名前 / ファイル | ライセンス | アクション |
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110002279417.pdf (2.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-27 | |||||
タイトル | ||||||
タイトル | 脳梗塞に関する実験的研究(第7報) : 微小血管への電子顕微鏡的アプローチ | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | experimental cerebral infarction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | electron microscopy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | vascular cast | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cryofracture | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | freeze-fracture replica | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
柴田, 尚武
× 柴田, 尚武× 福嶋, 政昭× 井上, 優× 堤, 健二× 森, 和夫 |
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著者別名 | ||||||
姓名 | Shibata, Shobu | |||||
著者別名 | ||||||
姓名 | Fukushima, Masaaki | |||||
著者別名 | ||||||
姓名 | Inoue, Masaru | |||||
著者別名 | ||||||
姓名 | Tsutsumi, Kenji | |||||
著者別名 | ||||||
姓名 | Mori, Kazuo | |||||
その他のタイトル | ||||||
その他のタイトル | Experimental Cerebral Infarction in the Dog (Part VII) : Electron Microscopic Studies of Microvasculature | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Experimental cerebral infarction was induced in dogs by injecting one or two silicone rubber cylinders through the cervical internal carotid artery. Twenty-four hours after embolization, the animals were sacrificed and changes of microvessels in the hemispheric infarct were investigated by the electron microscope. In addition to the usual ultrathin sectioning method, the vascular casting method using Mercox^<(R)> in combination with the cryofracture method, and the freeze-fracture replica method were also used. Gross specimens and histologic sections revealed that massive hemorrhagic areas were localized in the region of basal ganglia and petechial hemorrhages were observed in the corticomedullary junctional region of the affected hemisphere in the middle cerebral artery distribution. In ultrathin sections of arterioles obtained from the infarcted area of the basal ganglia, vacuolations and bleb-formations of the degenerative endothelial cells and smooth muscle cells, and duplications and fragmentations of the basal lamina appeared, while numerous red blood cells and fibrin materials were observed in the dilated subarachnoid space. In vascular casts of these 50 μm diameter arterioles, aneurysm-like dilatations were observed at their bifurcations, where numerous red blood cells and Mercox^<(R)> massively extravasated through the disrupted wall in the necrotized neuropils. Red blood cells in the dilated subarachnoid space were observed in the ultrathin sections of venules in the corticomedullary junctional region, but the degenerative changes were mild. In vascular casts of venules, leakage of Mercox^<(R)> was observed around the adventitia. It is suggested that a massive hemorrhagic infarction was caused by the disruption of arterioles in the perforating arterial terminal zone and petechial hemorrhagic infarction was caused by the disruption of venules in the cortical arterial terminal zone. No opening of tight junctions was recognized in the ultrathin sections of capillary endothelial cells in the ischemic cerebral cortex, but pinocytotic vesicles increased. In freeze-fracture replicas of capillary endothelia of both normal and ischemic cerebral cortices, tight junctions were seen as a network of ridges, composed of about 100 Å particles on the protoplasmic (p) face and grooves on the exoplasmic (e) face. Pinocytotic vesicles were seen as invaginations on the p face and as protrusions on the e face. The average number of pinocytotic vesicles per μm^2 was 7 on the luminal front in the normal cortex and 28 in the ischemic cortex. The size of pinocytotic vesicles was 0.62 × 10^<-2> μm on the p face of the normal cortex and 0.83 × 10^<-2> μm on the p face of the ischemic cortex. It is suggested that pinocytotic vesicles had a more important role in the increase of permeability in the cerebral capillary endothelial cells of the ischemic brain. | |||||
書誌情報 |
Neurologia medico-chirurgica 巻 24, 号 11, p. 831-839, 発行日 1984-11-15 |
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出版者 | ||||||
出版者 | 日本脳神経外科学会 | |||||
出版者別言語 | ||||||
The Japan Neurosurgical Society | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 04708105 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00358613 | |||||
権利 | ||||||
権利情報 | 日本脳神経外科学会 | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://ci.nii.ac.jp/naid/110002279417/ | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Neurologia medico-chirurgica, 24(11), pp.831-839; 1984 |