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Human papillomavirus genotypes in penile cancers from Japanese patients and HPV-induced NF-κB activation
http://hdl.handle.net/10069/24853
http://hdl.handle.net/10069/24853d8f9045e-144c-4a0d-916a-62fb82695144
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
OncLet1_267.pdf (292.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-04-04 | |||||
| タイトル | ||||||
| タイトル | Human papillomavirus genotypes in penile cancers from Japanese patients and HPV-induced NF-κB activation | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Human papillomavirus | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Nuclear factor-κB | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Penile cancer | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Senba, Masachika
× Senba, Masachika× Mori, Naoki× Wada, Akihiro× Fujita, Shuichi× Yasunami, Michio× Irie, Sumiko× Hayashi, Tomayoshi× Igawa, Tsukasa× Kanetake, Hiroshi× Takahara, Osamu× Toriyama, Kan |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The causal relationship between chronic inflammation and cancer is widely accepted. Numerous investigations have identified nuclear factor-κB (NF-κB) as an important modulator in driving chronic inflammation to cancer. This study aimed to determine the prevalence of human papillomavirus (HPV) in penile cancer in Japanese patients and whether NF-κB is subsequently overexpressed in penile cancer. Thirty-four specimens of penile tissue (16 malignant and 18 benign cases) were examined to determine the association of HPV infection. An in situ hybridization (ISH) method was used to detect and localize HPV-DNA. A sensitive HPV polymerase chain reaction (PCR) procedure was used for the detection of HPV-DNA, and DNA sequencing was used to identify the HPV genotype. HPV-DNA was detected in 37.5 and 75% of cases of penile cancer, using ISH and PCR, respectively. Our efforts to detect HPV genotypes were unsuccessful as HPV-DNA could not be extracted from these materials. Using ISH, a prevalence of 68.2% of HPV infection was found in penile cancer in Kenyan patients in east Africa. In the present study, all 9 HPV-positive cases, (100%) were NF-κB-positive in the nucleus and/or cytoplasm. In contrast, of the 25 HPV-negative cases, 15 (60%) were NF-κB-positive in the nucleus and/or cytoplasm. Therefore, ISH is a method which is able to prove infection of a large quantity of HPV more effectively when compared with PCR. Thus, a large quantity of HPV infection leads to the activity of NF-κB. The most prevalent genotype was the HPV-22 found in 83.3% of the penile cancer cases. In addition, HPV-11 was found in 81.8% of the non-cancer cases. For cases with a high level of infection, the activity of NF-κB increased compared with those with a low level of HPV infection. | |||||
| 書誌情報 |
Oncology Letters 巻 1, 号 2, p. 267-272, 発行日 2010-02-04 |
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| 出版者 | ||||||
| 出版者 | Spandidos Publications Ltd. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 17921074 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3892/ol_00000047 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Oncology Letters, 1(2), pp.267-272; 2010 | |||||
