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Basic fibroblast growth factor suppresses radiation-induced apoptosis and TP53 pathway in rat small intestine.
http://hdl.handle.net/10069/23880
http://hdl.handle.net/10069/238803891e441-f16d-41d0-9eaf-1adf7d6ff25a
名前 / ファイル | ライセンス | アクション |
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RadRes174_52.pdf (3.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-09-10 | |||||
タイトル | ||||||
タイトル | Basic fibroblast growth factor suppresses radiation-induced apoptosis and TP53 pathway in rat small intestine. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Matsuu-Matsuyama, Mutsumi
× Matsuu-Matsuyama, Mutsumi× Nakashima, Masahiro× Shichijo, Kazuko× Okaichi, Kumio× Nakayama, Toshiyuki× Sekine, Ichiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The effect of basic fibroblast growth factor (bFGF) was studied in radiation-induced apoptosis in rat jejunal crypt cells. Six-week-old male Wistar rats were administered 4 mg/kg bFGF intraperitoneally 25 h before receiving 8 Gy whole-body X rays. The jejunum was removed for analysis from time 0 to 120 h after irradiation. Villus length in control rats declined steadily until 72 h, while in bFGF-treated rats the villi were longer than in the controls until 48 h. Crypt lengths were similar to villi. bFGF treatment increased Ki-67-positive cells in the jejunal crypt at 0, 24 and 48 h. The treatment with bFGF reduced the number of apoptotic cells per jejunal crypt to 23% and 10% of the control values at 3 and 6 h, respectively, and increased numbers of mitotic cells significantly at 48 and 72 h. bFGF decreased the levels of TP53, CDKN1A, Puma and Cleaved caspase 3 at 3 h as detected by Western blot analyses. Our results suggest that bFGF protected against acute radiation-induced injury by suppressing the crypt apoptotic cells including the stem cells and promoted crypt cell proliferation. The inhibition of apoptosis thus might be related to suppression of the TP53 pathway. | |||||
書誌情報 |
Radiation research 巻 174, 号 1, p. 52-61, 発行日 2010-07 |
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出版者 | ||||||
出版者 | Radiation Research Society | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00337587 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00800228 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 20681799 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1667/RR1802.1 | |||||
権利 | ||||||
権利情報 | © 2010 by Radiation Research Society. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Radiation research, 174(1), pp.52-61; 2010 |