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Gene therapy for gastric diseases.
http://hdl.handle.net/10069/21982
http://hdl.handle.net/10069/2198288c2fa5d-5cad-458b-b6f6-625a68d273f5
名前 / ファイル | ライセンス | アクション |
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CGT8_187.pdf (601.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-06-11 | |||||
タイトル | ||||||
タイトル | Gene therapy for gastric diseases. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gastric cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gastric ulcer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gene delivery | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | stomach | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Fumoto, Shintaro
× Fumoto, Shintaro× Nishi, Junya× Nakamura, Junzo× Nishida, Koyo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Gene therapy for gastric cancer and gastric ulcer is a rationalized strategy since various genes correlate with these diseases. Since gene expressions in non-target tissues/cells cause side effects, a selective gene delivery system targeted to the stomach and/or cancer must be developed. The route of vector transfer (direct injection, systemic, intraperitoneal, gastric serosal surface and oral administration) is an important issue which can determine efficacy and safety. Strategies for cancer gene therapy can be categorized as suicide gene therapy, growth inhibition and apoptosis induction, immunotherapy, anti-angiogenesis, and others. Combination of the target gene with other genes and/or strategies such as chemotherapy and virotherapy is promising. Candidates for treatment of gastric ulcer are vascular endothelial growth factor, angiopoietin-1, serum response factor, and cationic host defense peptide cathelicidin. In this review, we discuss stomach- and cancer-targeted gene transfer methods and summarize gene therapy trials for gastric cancer and gastric ulcer. | |||||
書誌情報 |
Current gene therapy 巻 8, 号 3, p. 187-200, 発行日 2008-06 |
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出版者 | ||||||
出版者 | Bentham Science Publishers | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15665232 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11692320 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18537593 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2174/156652308784746431 | |||||
権利 | ||||||
権利情報 | (c) 2008 Bentham Science Publishers Ltd. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Current Gene Therapy, 8(3), pp.187-200; 2008 |