WEKO3
アイテム
{"_buckets": {"deposit": "c730ca5a-5e06-47a5-a8ca-0638632fa3d3"}, "_deposit": {"created_by": 2, "id": "16145", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "16145"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00016145", "sets": ["30"]}, "author_link": ["60654", "60656", "60653", "60655", "60652", "60657"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "878", "bibliographicPageStart": "867", "bibliographicVolumeNumber": "158", "bibliographic_titles": [{"bibliographic_title": "European journal of endocrinology"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "DESIGN AND METHODS: We have recently demonstrated that the adrenal cortices attached to aldosterone-producing adenoma (APA) contained microscopic subcapsular micronodules suggestive of active aldosterone production. In this study, we used in situ hybridization to investigate the mRNA expression of steroidogenic enzymes in the adrenal cortices attached to cortisol-producing adenoma (CPA) and clinically silent adenoma (non-functioning adenoma; NFA), in addition to APA. RESULTS: Microscopic subcapsular micronodules, which were several hundreds of micrometers in size and spheroid in shape, were observed in the cortices attached to CPA and NFA, as well as APA, at high frequency. Most of the cortical nodules in zona fasciculata to zona reticularis showed a suppressed steroidogenesis in the cortices attached to adenoma, but some expressed intensely all necessary steroidogenic enzyme mRNAs for cortisol synthesis. CONCLUSIONS: It is thus necessary to keep in mind, on the occasion of subtotal adrenalectomy, that lesions with the potential to later develop into functional adrenocortical nodules may be present in other parts of the ipsilateral or contralateral adrenal cortices.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "European journal of endocrinology, 158(6), pp.867-878; 2008", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "European Federation of Endocrine Societies"}]}, "item_2_relation_11": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "18505908", "subitem_relation_type_select": "PMID"}}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1530/EJE-07-0626", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright (c) 2008 by the Society of the European Journal of Endocrinology."}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10991304", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1479683X", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shigematsu, Kazuto"}], "nameIdentifiers": [{"nameIdentifier": "60652", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakagaki, Takehiro"}], "nameIdentifiers": [{"nameIdentifier": "60653", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamaguchi, Naohiro"}], "nameIdentifiers": [{"nameIdentifier": "60654", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawai, Kioko"}], "nameIdentifiers": [{"nameIdentifier": "60655", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakai, Hideki"}], "nameIdentifiers": [{"nameIdentifier": "60656", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahara, Osamu"}], "nameIdentifiers": [{"nameIdentifier": "60657", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "EJE158_867.pdf", "filesize": [{"value": "1.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1900000.0, "url": {"label": "EJE158_867.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/16145/files/EJE158_867.pdf"}, "version_id": "cbc3a584-af74-45fc-b7b5-f453f864899d"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "adrenocortical adenoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "remaining adrenal cortex", "subitem_subject_scheme": "Other"}, {"subitem_subject": "micronodule", "subitem_subject_scheme": "Other"}, {"subitem_subject": "steroidogenic enzyme", "subitem_subject_scheme": "Other"}, {"subitem_subject": "in situ hybridization", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Analysis of mRNA expression for steroidogenic enzymes in the remaining adrenal cortices attached to adrenocortical adenomas.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Analysis of mRNA expression for steroidogenic enzymes in the remaining adrenal cortices attached to adrenocortical adenomas."}]}, "item_type_id": "2", "owner": "2", "path": ["30"], "permalink_uri": "http://hdl.handle.net/10069/22028", "pubdate": {"attribute_name": "公開日", "attribute_value": "2009-07-17"}, "publish_date": "2009-07-17", "publish_status": "0", "recid": "16145", "relation": {}, "relation_version_is_last": true, "title": ["Analysis of mRNA expression for steroidogenic enzymes in the remaining adrenal cortices attached to adrenocortical adenomas."], "weko_shared_id": -1}
Analysis of mRNA expression for steroidogenic enzymes in the remaining adrenal cortices attached to adrenocortical adenomas.
http://hdl.handle.net/10069/22028
http://hdl.handle.net/10069/2202863010c40-6ba4-4096-8e02-0eb2d5c2caf5
名前 / ファイル | ライセンス | アクション |
---|---|---|
EJE158_867.pdf (1.9 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2009-07-17 | |||||
タイトル | ||||||
タイトル | Analysis of mRNA expression for steroidogenic enzymes in the remaining adrenal cortices attached to adrenocortical adenomas. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | adrenocortical adenoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | remaining adrenal cortex | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | micronodule | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | steroidogenic enzyme | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | in situ hybridization | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Shigematsu, Kazuto
× Shigematsu, Kazuto× Nakagaki, Takehiro× Yamaguchi, Naohiro× Kawai, Kioko× Sakai, Hideki× Takahara, Osamu |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | DESIGN AND METHODS: We have recently demonstrated that the adrenal cortices attached to aldosterone-producing adenoma (APA) contained microscopic subcapsular micronodules suggestive of active aldosterone production. In this study, we used in situ hybridization to investigate the mRNA expression of steroidogenic enzymes in the adrenal cortices attached to cortisol-producing adenoma (CPA) and clinically silent adenoma (non-functioning adenoma; NFA), in addition to APA. RESULTS: Microscopic subcapsular micronodules, which were several hundreds of micrometers in size and spheroid in shape, were observed in the cortices attached to CPA and NFA, as well as APA, at high frequency. Most of the cortical nodules in zona fasciculata to zona reticularis showed a suppressed steroidogenesis in the cortices attached to adenoma, but some expressed intensely all necessary steroidogenic enzyme mRNAs for cortisol synthesis. CONCLUSIONS: It is thus necessary to keep in mind, on the occasion of subtotal adrenalectomy, that lesions with the potential to later develop into functional adrenocortical nodules may be present in other parts of the ipsilateral or contralateral adrenal cortices. | |||||
書誌情報 |
European journal of endocrinology 巻 158, 号 6, p. 867-878, 発行日 2008-06 |
|||||
出版者 | ||||||
出版者 | European Federation of Endocrine Societies | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1479683X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10991304 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18505908 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1530/EJE-07-0626 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2008 by the Society of the European Journal of Endocrinology. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | European journal of endocrinology, 158(6), pp.867-878; 2008 |