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Single amino acid substitution in Plasmodium yoelii erythrocyte ligand determines its localization and controls parasite virulence
http://hdl.handle.net/10069/22077
http://hdl.handle.net/10069/220773f8ccbe4-2b24-4f42-831b-022648522dd8
名前 / ファイル | ライセンス | アクション |
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PNAS106_7167.pdf (716.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-08-11 | |||||
タイトル | ||||||
タイトル | Single amino acid substitution in Plasmodium yoelii erythrocyte ligand determines its localization and controls parasite virulence | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | erythrocyte | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | invasion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ligand | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | malaria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Plasmodium yoelii | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Otsuki, Hitoshi
× Otsuki, Hitoshi× Kaneko, Osamu× Thongkukiatkul, Amporn× Tachibana, Mayumi× Iriko, Hideyuki× Takeo, Satoru× Tsuboi, Takafumi× Torii, Motomi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The major virulence determinant of the rodent malaria parasite, Plasmodium yoelii, has remained unresolved since the discovery of the lethal line in the 1970s. Because virulence in this parasite correlates with the ability to invade different types of erythrocytes, we evaluated the potential role of the parasite erythrocyte binding ligand, PyEBL. We found 1 amino acid substitution in a domain responsible for intracellular trafficking between the lethal and nonlethal parasite lines and, furthermore, that the intracellular localization of PyEBL was distinct between these lines. Genetic modification showed that this substitution was responsible not only for PyEBL localization but also the erythrocyte-type invasion preference of the parasite and subsequently its virulence in mice. This previously unrecognized mechanism for altering an invasion phenotype indicates that subtle alterations of a malaria parasite ligand can dramatically affect host?pathogen interactions and malaria virulence. | |||||
書誌情報 |
Proceedings of the National Academy of Sciences 巻 106, 号 17, p. 7167-7172, 発行日 2009-04-28 |
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出版者 | ||||||
出版者 | the National Academy of Sciences | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00278424 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1091-6490 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10808769 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19346470 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1073/pnas.0811313106 | |||||
権利 | ||||||
権利情報 | Copyright c2009 by the National Academy of Sciences | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PNAS, 106(17), pp.7167-7172; 2009 |