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Single-cell observation of phagocytosis by human blood dendritic cells
http://hdl.handle.net/10069/22111
http://hdl.handle.net/10069/221119acf6ba1-f6fb-44c6-a2bd-a42e5b07dac5
名前 / ファイル | ライセンス | アクション |
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JJID61_294.pdf (329.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-08-26 | |||||
タイトル | ||||||
タイトル | Single-cell observation of phagocytosis by human blood dendritic cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ishimoto, Hiroshi
× Ishimoto, Hiroshi× Yanagihara, Katsunori× Araki, Nobuko× Mukae, Hiroshi× Sakamoto, Noriho× Izumikawa, Koichi× Seki, Masafumi× Miyazaki, Yoshitsugu× Hirakata, Yoichi× Mizuta, Yohei× Yasuda, Kenji× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Time-lapse video microscopic observation is useful for analysis of cell biology, especially in rapid response of immune cells. Dendritic cells (DCs) have multiple functions in the immune system, and DCs in peripheral blood play an especially important role at the front line of infection. We have developed a time-lapse video microscopic method for the evaluation of single myeloid DCs (MDC-1) from human peripheral blood. MDC-1 displayed generalized plasma membrane ruffling and phagocytosis of Pseudomonas aeruginosa. The morphological changes of MDC-1 increased following stimulation with P. aeruginosa but not after stimulation with supernatant from a P. aeruginosa culture. The activation of these morphological changes in MDC-1 could be quantitatively analyzed using the time-lapse video microscopy. This novel system may be useful for the evaluation of rapid response with human immune cells against bacterial infection. | |||||
書誌情報 |
Japanese Journal of Infectious Diseases 巻 61, 号 4, p. 294-297, 発行日 2008-07 |
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出版者 | ||||||
出版者 | National Institute of Infectious Diseases | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13446304 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA1132885X | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18653972 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Japanese Journal of Infectious Diseases, 61(4), pp. 294-297; 2008 |