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Elevation of Serum KL-6 Glycoprotein or Surfactant Protein-D in Adult T-cell Leukemia with Distinct Pulmonary Complications
http://hdl.handle.net/10069/22168
http://hdl.handle.net/10069/22168c04dcccc-927b-4ce5-9d5a-681ec953c2f4
名前 / ファイル | ライセンス | アクション |
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TJEM218_99.pdf (1.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-09-11 | |||||
タイトル | ||||||
タイトル | Elevation of Serum KL-6 Glycoprotein or Surfactant Protein-D in Adult T-cell Leukemia with Distinct Pulmonary Complications | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adult T-cell leukemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hematological malignancy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Interstitial pneumonia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Krebs von den Lungen-6 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Surfactant protein-D | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Osaka, Akemi
× Osaka, Akemi× Yanagihara, Katsunori× Yamada, Yasuaki× Hasegawa, Hiroo× Inokuchi, Naoko× Hayashi, Tomayoshi× Komoda, Minori× Nakamura, Shigeki× Aoyama, Muneo× Sawada, Takashi× Kamihira, Shimeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Patients with hematological malignancies frequently suffer from lung diseases as a complication. However, it is difficult to discriminate leukemic invasion into the lung from infectious pulmonary complications. The serum level of Krebs von den Lungen-6 (KL-6), which is a mucin-like glycoprotein, is increased in more than 70% of patients with interstitial pneumonia. Surfactant protein-D (SP-D) is produced mainly in the lung by alveolar type II and bronchiolar epithelial cells and is a useful serum marker for interstitial pneumonia. We therefore measured the levels of KL-6 and SP-D in sera from 128 patients (76 males and 52 females, mean age: 59 years) with hematological malignancies, including adult T-cell leukemia (ATL). Overall, the increase in KL-6 or SP-D, above each cut-off value (500 U/ml for KL-6 and 110 ng/ml for SP-D), was detected in 11 patients (8.6%) or 10 patients (7.8%), respectively. In contrast, among 67 ATL patients, 15 patients had high serum levels of KL-6 and/or SP-D; both were elevatedin 2 patients, only KL-6 was elevated in 6 patients and only SP-D was elevated in 7 patients. Thus, serum KL-6 and SP-D appear to be elevated in a mutually exclusive manner in ATL. Indeed, high serum levels of KL-6 were closely related to the stage of ATL, while the serum SP-D was elevated in ATL patients with pulmonary infection. In conclusion, the combined measurement of KL-6 and SP-D in ATL may become a useful means to discriminate leukemic pulmonary lesions from infectious pulmonary complications. | |||||
書誌情報 |
The Tohoku Journal of Experimental Medicine 巻 218, 号 2, p. 99-105, 発行日 2009-06 |
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出版者 | ||||||
出版者 | Tohoku University | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00408727 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1349-3329 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00863920 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1620/tjem.218.99 | |||||
権利 | ||||||
権利情報 | c 2009 Tohoku University Medical Press. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Tohoku Journal of Experimental Medicine, 218(2), pp.99-105 |