WEKO3
アイテム
{"_buckets": {"deposit": "e5fb5c9d-ac8c-46b6-8da2-3569a3c1a1d0"}, "_deposit": {"created_by": 2, "id": "16294", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "16294"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00016294", "sets": ["28"]}, "author_link": ["61464", "61457", "61462", "61459", "61460", "61466", "61468", "61458", "61461", "61463", "61465", "61467"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "26", "bibliographicPageEnd": "4400", "bibliographicPageStart": "4390", "bibliographicVolumeNumber": "30", "bibliographic_titles": [{"bibliographic_title": "Biomaterials"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Calcium-deficient hydroxyapatite (HA) granules with a unique spherical shape were prepared using an applied hydrothermal method. Spherical stoichiometric HA granules were also prepared by normal sintering and both granules were used for implantation into rat tibiae to compare the biological responses to each implant. Twelve and 24 weeks after implantation, the volume of calcium-deficient HA granules was significantly less than that of stoichiometric HA granules, and the biodegradability of calcium-deficient HA granules was confirmed. The larger number of osteoclasts, larger osteoblast surface and larger bone volume in the implanted area of calcium-deficient HA than those of stoichiometric HA suggested that osteoclastic resorption of calcium-deficient HA affected osteogenesis in that area. To analyze the direct contribution of osteoclasts to osteogenesis, C2C12 multipotent myoblastic cells, which have the potential to differentiate into osteoblasts in the presence of bone morphogenetic protein 2, were cultured with supernatants of osteoclasts cultured on calcium-deficient HA, stoichiometric HA, beta-tricalcium phosphate disks or plastic dishes, or bone marrow macrophages cultured on plastic dishes. Supernatants of osteoclasts but not bone marrow macrophages stimulated the expression of Runx2 and osteocalcin in C2C12 cells in concert with bone morphogenetic protein 2. The expression of alkaline phosphatase was stimulated with supernatants of osteoclasts cultured on ceramic disks. These results suggested that osteoclasts produced certain soluble factors which stimulated osteoblastic differentiation and they were thought to be associated with the induction of a larger osteoblast surface and bone volume in the animals implanted with calcium-deficient HA granules.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Biomaterials, 30(26), pp.4390-4400; 2009", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier BV"}]}, "item_2_relation_11": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "19481798", "subitem_relation_type_select": "PMID"}}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.biomaterials.2009.05.002", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c 2009 Elsevier Ltd. All rights reserved."}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11522637", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "01429612", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1878-5905", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Gonda, Yoshinori"}], "nameIdentifiers": [{"nameIdentifier": "61457", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ioku, Koji"}], "nameIdentifiers": [{"nameIdentifier": "61458", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibata, Yasuaki"}], "nameIdentifiers": [{"nameIdentifier": "61459", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okuda, Takatoshi"}], "nameIdentifiers": [{"nameIdentifier": "61460", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawachi, Giichiro"}], "nameIdentifiers": [{"nameIdentifier": "61461", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamitakahara, Masanobu"}], "nameIdentifiers": [{"nameIdentifier": "61462", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murayama, Hisashi"}], "nameIdentifiers": [{"nameIdentifier": "61463", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hideshima, Katsumi"}], "nameIdentifiers": [{"nameIdentifier": "61464", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamihira, Shimeru"}], "nameIdentifiers": [{"nameIdentifier": "61465", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yonezawa, Ikuho"}], "nameIdentifiers": [{"nameIdentifier": "61466", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kurosawa, Hisashi"}], "nameIdentifiers": [{"nameIdentifier": "61467", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikeda, Tohru"}], "nameIdentifiers": [{"nameIdentifier": "61468", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Biomaterials30_4390.pdf", "filesize": [{"value": "8.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 8600000.0, "url": {"label": "Biomaterials30_4390.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/16294/files/Biomaterials30_4390.pdf"}, "version_id": "6ddc0471-68eb-4519-844a-cf3037b8ceb1"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Hydroxyapatite", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Bone graft", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cell culture", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Osteoblast", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Osteoclast", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Stimulatory effect of hydrothermally synthesized biodegradable hydroxyapatite granules on osteogenesis and direct association with osteoclasts.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Stimulatory effect of hydrothermally synthesized biodegradable hydroxyapatite granules on osteogenesis and direct association with osteoclasts."}]}, "item_type_id": "2", "owner": "2", "path": ["28"], "permalink_uri": "http://hdl.handle.net/10069/22172", "pubdate": {"attribute_name": "公開日", "attribute_value": "2009-09-15"}, "publish_date": "2009-09-15", "publish_status": "0", "recid": "16294", "relation": {}, "relation_version_is_last": true, "title": ["Stimulatory effect of hydrothermally synthesized biodegradable hydroxyapatite granules on osteogenesis and direct association with osteoclasts."], "weko_shared_id": -1}
Stimulatory effect of hydrothermally synthesized biodegradable hydroxyapatite granules on osteogenesis and direct association with osteoclasts.
http://hdl.handle.net/10069/22172
http://hdl.handle.net/10069/22172686c55fb-9a18-4be5-9895-0ced2f057b2f
名前 / ファイル | ライセンス | アクション |
---|---|---|
Biomaterials30_4390.pdf (8.6 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2009-09-15 | |||||
タイトル | ||||||
タイトル | Stimulatory effect of hydrothermally synthesized biodegradable hydroxyapatite granules on osteogenesis and direct association with osteoclasts. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hydroxyapatite | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bone graft | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cell culture | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Osteoblast | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Osteoclast | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Gonda, Yoshinori
× Gonda, Yoshinori× Ioku, Koji× Shibata, Yasuaki× Okuda, Takatoshi× Kawachi, Giichiro× Kamitakahara, Masanobu× Murayama, Hisashi× Hideshima, Katsumi× Kamihira, Shimeru× Yonezawa, Ikuho× Kurosawa, Hisashi× Ikeda, Tohru |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Calcium-deficient hydroxyapatite (HA) granules with a unique spherical shape were prepared using an applied hydrothermal method. Spherical stoichiometric HA granules were also prepared by normal sintering and both granules were used for implantation into rat tibiae to compare the biological responses to each implant. Twelve and 24 weeks after implantation, the volume of calcium-deficient HA granules was significantly less than that of stoichiometric HA granules, and the biodegradability of calcium-deficient HA granules was confirmed. The larger number of osteoclasts, larger osteoblast surface and larger bone volume in the implanted area of calcium-deficient HA than those of stoichiometric HA suggested that osteoclastic resorption of calcium-deficient HA affected osteogenesis in that area. To analyze the direct contribution of osteoclasts to osteogenesis, C2C12 multipotent myoblastic cells, which have the potential to differentiate into osteoblasts in the presence of bone morphogenetic protein 2, were cultured with supernatants of osteoclasts cultured on calcium-deficient HA, stoichiometric HA, beta-tricalcium phosphate disks or plastic dishes, or bone marrow macrophages cultured on plastic dishes. Supernatants of osteoclasts but not bone marrow macrophages stimulated the expression of Runx2 and osteocalcin in C2C12 cells in concert with bone morphogenetic protein 2. The expression of alkaline phosphatase was stimulated with supernatants of osteoclasts cultured on ceramic disks. These results suggested that osteoclasts produced certain soluble factors which stimulated osteoblastic differentiation and they were thought to be associated with the induction of a larger osteoblast surface and bone volume in the animals implanted with calcium-deficient HA granules. | |||||
書誌情報 |
Biomaterials 巻 30, 号 26, p. 4390-4400, 発行日 2009-09 |
|||||
出版者 | ||||||
出版者 | Elsevier BV | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01429612 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1878-5905 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11522637 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19481798 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.biomaterials.2009.05.002 | |||||
権利 | ||||||
権利情報 | c 2009 Elsevier Ltd. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biomaterials, 30(26), pp.4390-4400; 2009 |