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Polymorphisms of PTPN11 coding SHP-2 as biomarkers for ulcerative colitis susceptibility in the Japanese population.
http://hdl.handle.net/10069/22204
http://hdl.handle.net/10069/22204999ee47f-2b18-4693-a21b-839c8551ad4a
名前 / ファイル | ライセンス | アクション |
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JCI29_303.pdf (145.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-10-01 | |||||
タイトル | ||||||
タイトル | Polymorphisms of PTPN11 coding SHP-2 as biomarkers for ulcerative colitis susceptibility in the Japanese population. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Candidate gene-based association study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Japanese population | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Polymorphisms | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PTPN11 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ulcerative colitis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Narumi, Yukiko
× Narumi, Yukiko× Isomoto, Hajime× Shiota, Mizuho× Sato, Kayoko× Kondo, Shinji× Machida, Haruhisa× Yanagihara, Katsunori× Mizuta, Yohei× Kohno, Shigeru× Tsukamoto, Kazuhiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | OBJECTIVE: To identify genetic determinants of inflammatory bowel disease (IBD), we examined an association between polymorphisms of both the programmed cell death 1 gene (PDCD1) and the src homology 2 domain-containing tyrosine phosphatase 2 gene (PTPN11) and susceptibility to IBD. METHODS: Study subjects comprised 114 patients with ulcerative colitis (UC), 83 patients with Crohn's disease, and 200 healthy control subjects. Five single nucleotide polymorphisms (SNPs) in PDCD1 and PTPN11 were detected by polymerase chain reaction restriction fragment length polymorphism. Subsequently, haplotypes composed of the two SNPs in PTPN11 were constructed. RESULTS: The frequencies of the Hap 1 haplotype and its homozygous Hap 1/Hap 1 diplotype of PTPN11 were significantly increased in UC patients compared to control subjects (P = 0.011 and P = 0.030, respectively). While no association was found for PDCD1 for UC or CD and none for PTPN11 for CD. CONCLUSION: PTPN11 is a genetic determinant for the pathogenesis of UC, and haplotyping of PTPN11 may be useful as a genetic biomarker to identify high-risk individuals susceptible to UC. | |||||
書誌情報 |
Journal of clinical immunology 巻 29, 号 3, p. 303-310, 発行日 2009-05 |
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出版者 | ||||||
出版者 | Springer Netherlands | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 02719142 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1573-2592 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10620335 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19160029 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s10875-008-9272-6 | |||||
権利 | ||||||
権利情報 | c 2009 Springer Science+Business Media, LLC. | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of clinical immunology, 29(3), pp.303-310; 2009 |