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Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis.
http://hdl.handle.net/10069/22251
http://hdl.handle.net/10069/2225199772803-6502-44da-83e3-e4b76aa71095
名前 / ファイル | ライセンス | アクション |
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AntRes84_150.pdf (1.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-10-16 | |||||
タイトル | ||||||
タイトル | Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Antiviral effect | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Apoptosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Coxsackie virus B3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Phyllaemblicin B | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Viral myocarditis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Wang, Ya-Feng
× Wang, Ya-Feng× Wang, Xiao-Yan× Ren, Zhe× Qian, Chui-Wen× Li, Yi-Cheng× Kitazato, Kaio× Wang, Qing-Duan× Zhang, Yan× Zheng, Li-Yun× Jiang, Jin-Hua× Yang, Chong-Ren× Liu, Qing× Zhang, Ying-Jun× Wang, Yi-Fei |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Coxsackie virus B3 (CVB3) is believed to be a major contributor to viral myocarditis since virus-associated apoptosis plays a role in the pathogenesis of experimental myocarditis. In this study, we investigated the in vitro and in vivo antiviral activities of Phyllaemblicin B, the main ellagitannin compound isolated from Phyllanthus emblica, a Chinese herb medicine, against CVB3. Herein we report that Phyllaemblicin B inhibited CVB3-mediated cytopathic effects on HeLa cells with an IC(50) value of 7.75+/-0.15microg/mL. In an in vivo assay, treatment with 12mgkg(-1)d(-1) Phyllaemblicin B reduced cardiac CVB3 titers, decreased the activities of LDH and CK in murine serum, and alleviated pathological damages of cardiac muscle in myocarditic mice. Moreover, Phyllaemblicin B clearly inhibited CVB3-associated apoptosis effects both in vitro and in vivo. These results show that Phyllaemblicin B exerts significant antiviral activities against CVB3. Therefore, Phyllaemblicin B may represent a potential therapeutic agent for viral myocarditis. | |||||
書誌情報 |
Antiviral research 巻 84, 号 2, p. 150-158, 発行日 2009-11 |
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出版者 | ||||||
出版者 | Elsevier BV | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01663542 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1872-9096 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10623661 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19699238 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.antiviral.2009.08.004 | |||||
権利 | ||||||
権利情報 | Copyright c 2009 Elsevier B.V. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Antiviral research, 84(2), pp.150-158; 2009 |