WEKO3
アイテム
{"_buckets": {"deposit": "581eb207-c528-4e16-8362-a66ebc168e15"}, "_deposit": {"created_by": 2, "id": "16399", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "16399"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00016399", "sets": ["11"]}, "author_link": ["62119", "62121", "62120", "62116", "62118", "62117", "62113", "62114", "62115"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "377", "bibliographicPageStart": "371", "bibliographicVolumeNumber": "135", "bibliographic_titles": [{"bibliographic_title": "Journal of cancer research and clinical oncology"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "PURPOSE: This study aimed to evaluate serum cytochrome c (cyto-c) levels as a novel role of tumor marker in patients with operable malignant tumors. METHODS: Serum cyto-c levels and lactate dehydrogenase (LD) activity were measured in a total of 257 cases (232 malignant and 25 benign). To identify the relationship between serum cyto-c and current tumor markers, six variables, such as gender, age, invasion, lymph node metastasis, distant metastasis, and LD, were analyzed by uni- and multivariate regression analysis methods. The test performance of serum cyto-c for the prediction of malignant behavior was evaluated by receiver operating characteristic (ROC) curves. RESULTS: The serum cyto-c level was significantly higher in patients with malignant tumors than patients with benign tumors (20.6 vs. 15.5 ng/mL; P = 0.017, Mann-Whitney U test). No difference in the levels among subtypes of cancer was found, indicating that the change in serum cyto-c levels reflect cancer individually and not specific subtypes of cancer. The survival in patients with serum cyto-c levels over 40 ng/mL was poor (Kaplan-Meier test, P \u003c 0.0001, Hazard ratio 16.76, 95% confidential interval 4.45-63.04). Multiple linear regression analyses disclosed the close association of serum cyto-c levels with invasion (P = 0.0004), metastasis (P = 0.0262) except for regional lymph node metastasis, and activity of serum LD (P \u003c 0.0001), all of which are well known to represent malignant behavior. Conversely, the measurement of serum cyto-c was verified to have excellent diagnostic accuracy of 0.802 and 0.781 for the detection of invasion and metastasis (the area under curves of the constructed ROCs). CONCLUSION: Serum cyto-c is a potent tumor marker as a predictor for malignant potential in cancers.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Journal of cancer research and clinical oncology, 135(3), pp.371-377; 2009", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer Berlin"}]}, "item_2_relation_11": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "18825408", "subitem_relation_type_select": "PMID"}}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1007/s00432-008-0479-y", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c Springer-Verlag 2008"}, {"subitem_rights": "The original publication is available at www.springerlink.com"}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA0025708X", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "01715216", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1432-1335", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Osaka, Akemi"}], "nameIdentifiers": [{"nameIdentifier": "62113", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hasegawa, Hiroo"}], "nameIdentifiers": [{"nameIdentifier": "62114", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamada, Yasuaki"}], "nameIdentifiers": [{"nameIdentifier": "62115", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yanagihara, Katsunori"}], "nameIdentifiers": [{"nameIdentifier": "62116", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayashi, Tomayoshi"}], "nameIdentifiers": [{"nameIdentifier": "62117", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mine, Mariko"}], "nameIdentifiers": [{"nameIdentifier": "62118", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aoyama, Muneo"}], "nameIdentifiers": [{"nameIdentifier": "62119", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sawada, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "62120", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamihira, Shimeru"}], "nameIdentifiers": [{"nameIdentifier": "62121", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "JCRCO135_371.pdf", "filesize": [{"value": "423.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 423000.0, "url": {"label": "JCRCO135_371.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/16399/files/JCRCO135_371.pdf"}, "version_id": "53bdef36-5c6b-48d5-8469-7b1f9c8068a1"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Cytochrome c", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Metastatic potential", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Prediction", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tumor marker", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "A novel role of serum cytochrome c as a tumor marker in patients with operable cancer.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "A novel role of serum cytochrome c as a tumor marker in patients with operable cancer."}]}, "item_type_id": "2", "owner": "2", "path": ["11"], "permalink_uri": "http://hdl.handle.net/10069/22278", "pubdate": {"attribute_name": "公開日", "attribute_value": "2009-10-20"}, "publish_date": "2009-10-20", "publish_status": "0", "recid": "16399", "relation": {}, "relation_version_is_last": true, "title": ["A novel role of serum cytochrome c as a tumor marker in patients with operable cancer."], "weko_shared_id": 2}
A novel role of serum cytochrome c as a tumor marker in patients with operable cancer.
http://hdl.handle.net/10069/22278
http://hdl.handle.net/10069/22278b74267db-9178-47cf-8aea-74721b7def27
名前 / ファイル | ライセンス | アクション |
---|---|---|
JCRCO135_371.pdf (423.0 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2009-10-20 | |||||
タイトル | ||||||
タイトル | A novel role of serum cytochrome c as a tumor marker in patients with operable cancer. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytochrome c | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Metastatic potential | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prediction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tumor marker | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Osaka, Akemi
× Osaka, Akemi× Hasegawa, Hiroo× Yamada, Yasuaki× Yanagihara, Katsunori× Hayashi, Tomayoshi× Mine, Mariko× Aoyama, Muneo× Sawada, Takashi× Kamihira, Shimeru |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | PURPOSE: This study aimed to evaluate serum cytochrome c (cyto-c) levels as a novel role of tumor marker in patients with operable malignant tumors. METHODS: Serum cyto-c levels and lactate dehydrogenase (LD) activity were measured in a total of 257 cases (232 malignant and 25 benign). To identify the relationship between serum cyto-c and current tumor markers, six variables, such as gender, age, invasion, lymph node metastasis, distant metastasis, and LD, were analyzed by uni- and multivariate regression analysis methods. The test performance of serum cyto-c for the prediction of malignant behavior was evaluated by receiver operating characteristic (ROC) curves. RESULTS: The serum cyto-c level was significantly higher in patients with malignant tumors than patients with benign tumors (20.6 vs. 15.5 ng/mL; P = 0.017, Mann-Whitney U test). No difference in the levels among subtypes of cancer was found, indicating that the change in serum cyto-c levels reflect cancer individually and not specific subtypes of cancer. The survival in patients with serum cyto-c levels over 40 ng/mL was poor (Kaplan-Meier test, P < 0.0001, Hazard ratio 16.76, 95% confidential interval 4.45-63.04). Multiple linear regression analyses disclosed the close association of serum cyto-c levels with invasion (P = 0.0004), metastasis (P = 0.0262) except for regional lymph node metastasis, and activity of serum LD (P < 0.0001), all of which are well known to represent malignant behavior. Conversely, the measurement of serum cyto-c was verified to have excellent diagnostic accuracy of 0.802 and 0.781 for the detection of invasion and metastasis (the area under curves of the constructed ROCs). CONCLUSION: Serum cyto-c is a potent tumor marker as a predictor for malignant potential in cancers. | |||||
書誌情報 |
Journal of cancer research and clinical oncology 巻 135, 号 3, p. 371-377, 発行日 2009-03 |
|||||
出版者 | ||||||
出版者 | Springer Berlin | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01715216 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1432-1335 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA0025708X | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18825408 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00432-008-0479-y | |||||
権利 | ||||||
権利情報 | c Springer-Verlag 2008 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of cancer research and clinical oncology, 135(3), pp.371-377; 2009 |