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Elevated expression of ERK 2 in human tumor cells chronically treated with PD98059.
http://hdl.handle.net/10069/22290
http://hdl.handle.net/10069/22290998e3614-a0d8-47d3-a19b-435d338a9d3e
名前 / ファイル | ライセンス | アクション |
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BBRC345_1481.pdf (233.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-10-27 | |||||
タイトル | ||||||
タイトル | Elevated expression of ERK 2 in human tumor cells chronically treated with PD98059. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MEK inhibitor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chronic exposure | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ERK 2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tumor cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Proliferation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kanda, Shigeru
× Kanda, Shigeru× Kanetake, Hiroshi× Miyata, Yasuyoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined the effect of chronic exposure of tumor cells to a mitogen-activated protein kinase/extracellular signal-regulated kinases (ERK) kinase inhibitor, PD98059, on cell proliferation was investigated. Human renal carcinoma cells (ACHN) and prostatic carcinoma cells (DU145) were cultured in the presence of PD98059 for more than 4 weeks (denoted ACHN (PD) cells and DU145 (PD) cells, respectively) and proliferation and signal transduction pathways were examined. PD98059 significantly inhibited the proliferation of parental cells. However, PD98059 failed to inhibit proliferation of ACHN (PD) and DU145 (PD) cells significantly. Expression of ERK 1 and 2 was elevated in these cells. These phenotypes were reversible. Downregulation of ERK 2, but not ERK 1, by small interfering RNA significantly inhibited the proliferation of ACHN (PD) and DU145 (PD) cells. Taken together, chronic exposure of tumor cells to PD98059 induced elevated expression of ERK 2, which was associated with decreased sensitivity of cellular proliferation to PD98059. | |||||
書誌情報 |
Biochemical and biophysical research communications 巻 345, 号 4, p. 1481-1486, 発行日 2006-07-14 |
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出版者 | ||||||
出版者 | Elsevier Inc | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006291X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1090-2104 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00564395 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 16729971 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.bbrc.2006.05.048 | |||||
権利 | ||||||
権利情報 | Copyright c 2006 Elsevier Inc. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biochemical and biophysical research communications, 345(4), pp.1481-1486; 2006 |