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Fibroblast growth factor-2 induces the activation of Src through Fes, which regulates focal adhesion disassembly.
http://hdl.handle.net/10069/22291
http://hdl.handle.net/10069/22291e3f3ecf4-69ae-4bee-a2a5-a6a1836a0108
名前 / ファイル | ライセンス | アクション |
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ECR312_3015.pdf (413.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-10-27 | |||||
タイトル | ||||||
タイトル | Fibroblast growth factor-2 induces the activation of Src through Fes, which regulates focal adhesion disassembly. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | FGF-2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Src | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | FAK | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Endothelial cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Focal adhesion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Migration | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kanda, Shigeru
× Kanda, Shigeru× Miyata, Yasuyoshi× Kanetake, Hiroshi× Smithgall, Thomas E |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cell migration is regulated by focal adhesion (FA) turnover. Fibroblast growth factor-2 (FGF-2) induces FA disassembly in the murine brain capillary endothelial cell line IBE, leading to FGF-2-directed chemotaxis. We previously showed that activation of Src and Fes by FGF-2 was involved in chemotaxis of IBE cells. In this study, we examined the interplay between Src and Fes. FGF-2 treatment decreased the number of FA in IBE cells, but not in cells expressing dominant-negative Fes (denoted KE5-15 cells). FGF-2 induced the activation of Src and subsequent binding to and phosphorylation of Cas in IBE cells, but not in KE5-15 cells. Focal adhesion kinase (FAK) activation and tyrosine phosphorylation by Src were also delayed in KE5-15 cells compared to parental cells. FGF-2 induced activation of Src within FA in IBE cells, but not in KE5-15 cells. Downregulation of Fes or FAK using small interfering RNA diminished Src activation by FGF-2 within FA. These findings suggest that activation of Fes by FGF-2 enhances FAK-dependent activation of Src within FA, promoting FGF-2-induced disassembly of focal adhesions. | |||||
書誌情報 |
Experimental cell research 巻 312, 号 16, p. 3015-3022, 発行日 2006-10-01 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00144827 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1090-2422 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00641011 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 16884713 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.yexcr.2006.06.032 | |||||
権利 | ||||||
権利情報 | Copyright c 2006 Published by Elsevier Inc. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Experimental cell research, 312(16), pp.3015-3022; 2006 |