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Downregulation of Fes inhibits VEGF-A-induced chemotaxis and capillary-like morphogenesis by cultured endothelial cells.
http://hdl.handle.net/10069/22293
http://hdl.handle.net/10069/22293594ab534-3c0f-4164-b4d5-4361f5eb1072
名前 / ファイル | ライセンス | アクション |
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JCMM11_495.pdf (353.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-10-27 | |||||
タイトル | ||||||
タイトル | Downregulation of Fes inhibits VEGF-A-induced chemotaxis and capillary-like morphogenesis by cultured endothelial cells. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | VEGF-A | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | siRNA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | endothelial cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chemotaxis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | capillary-like morphogenesis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kanda, Shigeru
× Kanda, Shigeru× Kanetake, Hiroshi× Miyata, Yasuyoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The aim of this study was to determine whether the downregulation of endogenous Fes by siRNA in cultured endothelial cells affects vascular endothelial growth factor-A (VEGF-A)-induced chemotaxis and capillary-like morphogenesis, which are considered as angiogenic cellular responses in vitro. VEGF-A-treatment induced autophosphorylation of Fes in cultured endothelial cells. LY294002, a phosphoinositide 3-kinase inhibitor, significantly inhibited VEGF-A-induced chemotaxis and capillary-like morphogenesis. Downregulation of Fes attenuated these VEGF-A-induced cellular responses but LY294002 did not produce further inhibition of these responses. Downregulation of Fes neither affected VEGF-A-induced autophosphorylation of VEGF receptor 2 nor mitogen-activated protein kinase activation, but markedly decreased Akt activation. Taken together, our novel results indicate the involvement of Fes in VEGF-A-induced cellular responses by cultured endothelial cells. | |||||
書誌情報 |
Journal of cellular and molecular medicine 巻 11, 号 3, p. 495-501, 発行日 2007-05-22 |
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出版者 | ||||||
出版者 | Blackwell Publishing Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15821838 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11644758 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 17521372 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/j.1582-4934.2007.00034.x | |||||
権利 | ||||||
権利情報 | c 2009 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd | |||||
権利 | ||||||
権利情報 | The definitive version is available at www.blackwell-synergy.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of cellular and molecular medicine, 11(3), pp.495-501; 2007 |