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Hemoglobin-mediated selenium export from red blood cells.
http://hdl.handle.net/10069/22294
http://hdl.handle.net/10069/222943238f048-cd1a-4717-b692-d5fba7006e41
名前 / ファイル | ライセンス | アクション |
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JBIC13_471.pdf (555.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-10-27 | |||||
タイトル | ||||||
タイトル | Hemoglobin-mediated selenium export from red blood cells. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Band 3 protein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hemoglobin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Inside-out vesicle | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Red blood cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Selenium | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Haratake, Mamoru
× Haratake, Mamoru× Fujimoto, Katsuyoshi× Hirakawa, Ritsuko× Ono, Masahiro× Nakayama, Morio |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | On the basis of the fact that selenium from selenite binds to hemoglobin (Hb), we investigated the missing process in the selenium export from red blood cells (RBCs), i.e., the transfer of selenium bound to Hb to RBC membrane proteins. To elucidate the molecular events of the Hb-associated selenium export from RBC, a Hb-Se complex was synthesized from thiol-exchange of Cys-beta93 in Hb with penicillamine-substituted glutathione selenotrisulfide, as a model of major metabolic intermediates, and then interactions between the Hb-Se complex and RBC inside-out vesicles (IOVs) were examined. Selenium bound to Hb was transferred to the IOV membrane on the basis of the intrinsic interactions between Hb and the cytoplasmic domains of band 3 protein (CDB3). The observed selenium transfer was inhibited by the pretreatments of IOVs with iodoacetamide and the alpha-chymotrypsin digestion, indicating that the Hb mediates the selenium transfer to the thiol groups of CDB3. In addition, it was found that deoxygenated Hb, with a high binding affinity for CDB3, more favorably transferred selenium to the IOV membranes than oxygenated Hb, with a low affinity. When selenium export from RBC to the plasma was examined by continuously introducing nitrogen gas, the selenium export rate was promoted with an increase in the rate of deoxygenated Hb. Overall, these data suggested that Hb could possibly play a role in the selenium export from RBC treated with selenite in an oxygen-linked fashion. | |||||
書誌情報 |
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 巻 13, 号 3, p. 471-479, 発行日 2008-03 |
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出版者 | ||||||
出版者 | Springer Berlin | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09498257 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1432-1327 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11133001 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18175156 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00775-007-0335-6 | |||||
権利 | ||||||
権利情報 | c SBIC 2007 | |||||
権利 | ||||||
権利情報 | The original publication is available on SpringerLink at http://link.springer.de | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関係URI | ||||||
関連名称 | http://www.springerlink.com/content/038v116585245470/ | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Biological Inorganic Chemistry, 13(3), pp.471-479; 2008 |