WEKO3
アイテム
{"_buckets": {"deposit": "d058772c-5971-46fc-b01c-af7fdb058ece"}, "_deposit": {"created_by": 2, "id": "16478", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "16478"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00016478", "sets": ["30"]}, "author_link": ["62615", "62614", "62617", "62613", "62616", "62612", "62611"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "652", "bibliographicPageStart": "646", "bibliographicVolumeNumber": "44", "bibliographic_titles": [{"bibliographic_title": "Experimental gerontology"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Calorie restriction (CR) and a reduced growth hormone (GH) signal affect insulin sensitivity and lifespan in mammals in a similar manner. We investigated the effects of CR and moderate inhibition of GH on glucose-stimulated activation of insulin signaling and the expression of genes related to fat metabolism in white adipose tissue (WAT) in rats. We used 10-month-old male, wild-type (W) Wistar rats, fed ad libitum (AL) or a 30% CR diet from 6weeks of age, and transgenic (Tg) rats with moderately suppressed GH signaling. Rats were killed 15min after an intraperitoneal injection of glucose or saline. In control W-AL rats, the levels of serum insulin, phosphorylated (p) insulin receptor (pY-IR), p-Akt, and the expression of glucose transporter (Glut) 4 in the membrane fraction were greater in the glucose-injected group than in the saline-injected group, indicating significant activation of insulin signaling in response to glucose loading. In the W-CR and Tg-AL rats, the serum insulin and pY-IR levels were lower than those in the W-AL rats. The Akt-Glut pathway was up-regulated even after saline-injection. Expression levels of adipogenic and lipogenic genes including PPARgamma, adiponectin, and its receptors, were higher in the W-CR rats than in the W-AL and Tg-AL rats. The present findings indicate adipose tissue metabolic profiles specific to CR.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Experimental gerontology, 44(10), pp.646-652; 2009", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier Inc."}]}, "item_2_relation_11": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "19646410", "subitem_relation_type_select": "PMID"}}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.exger.2009.07.002", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright c 2009 Elsevier Inc. All rights reserved."}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00641077", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05315565", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1873-6815", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Park, Seongjoon"}], "nameIdentifiers": [{"nameIdentifier": "62611", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Komatsu, Toshimitsu"}], "nameIdentifiers": [{"nameIdentifier": "62612", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayashi, Hiroko"}], "nameIdentifiers": [{"nameIdentifier": "62613", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Trindade, Lucas Siqueira"}], "nameIdentifiers": [{"nameIdentifier": "62614", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamaza, Haruyoshi"}], "nameIdentifiers": [{"nameIdentifier": "62615", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Chiba, Takuya"}], "nameIdentifiers": [{"nameIdentifier": "62616", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimokawa, Isao"}], "nameIdentifiers": [{"nameIdentifier": "62617", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ExpGer44_646.pdf", "filesize": [{"value": "340.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 340400.0, "url": {"label": "ExpGer44_646.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/16478/files/ExpGer44_646.pdf"}, "version_id": "d394f346-88c4-44e1-8e6a-cf0754685049"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Adipose tissue", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Calorie restriction", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Glucose uptake", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Growth hormone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Insulin signal", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling."}]}, "item_type_id": "2", "owner": "2", "path": ["30"], "permalink_uri": "http://hdl.handle.net/10069/22353", "pubdate": {"attribute_name": "公開日", "attribute_value": "2009-11-17"}, "publish_date": "2009-11-17", "publish_status": "0", "recid": "16478", "relation": {}, "relation_version_is_last": true, "title": ["Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling."], "weko_shared_id": 2}
Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling.
http://hdl.handle.net/10069/22353
http://hdl.handle.net/10069/22353a3cde702-eb14-4543-8445-98219b04e783
名前 / ファイル | ライセンス | アクション |
---|---|---|
ExpGer44_646.pdf (340.4 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2009-11-17 | |||||
タイトル | ||||||
タイトル | Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adipose tissue | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Calorie restriction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Glucose uptake | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Growth hormone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Insulin signal | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Park, Seongjoon
× Park, Seongjoon× Komatsu, Toshimitsu× Hayashi, Hiroko× Trindade, Lucas Siqueira× Yamaza, Haruyoshi× Chiba, Takuya× Shimokawa, Isao |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Calorie restriction (CR) and a reduced growth hormone (GH) signal affect insulin sensitivity and lifespan in mammals in a similar manner. We investigated the effects of CR and moderate inhibition of GH on glucose-stimulated activation of insulin signaling and the expression of genes related to fat metabolism in white adipose tissue (WAT) in rats. We used 10-month-old male, wild-type (W) Wistar rats, fed ad libitum (AL) or a 30% CR diet from 6weeks of age, and transgenic (Tg) rats with moderately suppressed GH signaling. Rats were killed 15min after an intraperitoneal injection of glucose or saline. In control W-AL rats, the levels of serum insulin, phosphorylated (p) insulin receptor (pY-IR), p-Akt, and the expression of glucose transporter (Glut) 4 in the membrane fraction were greater in the glucose-injected group than in the saline-injected group, indicating significant activation of insulin signaling in response to glucose loading. In the W-CR and Tg-AL rats, the serum insulin and pY-IR levels were lower than those in the W-AL rats. The Akt-Glut pathway was up-regulated even after saline-injection. Expression levels of adipogenic and lipogenic genes including PPARgamma, adiponectin, and its receptors, were higher in the W-CR rats than in the W-AL and Tg-AL rats. The present findings indicate adipose tissue metabolic profiles specific to CR. | |||||
書誌情報 |
Experimental gerontology 巻 44, 号 10, p. 646-652, 発行日 2009-10 |
|||||
出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05315565 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1873-6815 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00641077 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19646410 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.exger.2009.07.002 | |||||
権利 | ||||||
権利情報 | Copyright c 2009 Elsevier Inc. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Experimental gerontology, 44(10), pp.646-652; 2009 |