WEKO3
アイテム
{"_buckets": {"deposit": "f054fc86-ae05-472a-8e7a-f80a7458b5d4"}, "_deposit": {"created_by": 2, "id": "16615", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "16615"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00016615", "sets": ["30"]}, "author_link": ["63698", "63695", "63692", "63699", "63694", "63696", "63691", "63697", "63693"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "402", "bibliographicPageStart": "398", "bibliographicVolumeNumber": "76", "bibliographic_titles": [{"bibliographic_title": "Respiration; international review of thoracic diseases"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "BACKGROUND: Little is understood about the additive effects of leukotriene receptor antagonists (LTRA) on asthmatics currently medicated with inhaled corticosteroids (ICS) and long-acting beta(2)-agonists (LABA). OBJECTIVES: The present study examines the anti-inflammatory effects of the LTRA pranlukast in addition to ICS and LABA, among asthmatic patients with normal pulmonary function and unremarkable clinical symptoms. METHODS: Fifteen adult asthmatics participated in a 2-month, open-label, uncontrolled, prospective, multicenter, observational trial. Patients stabilized (predicted forced expiratory volume in 1 s \u003e80%) by medication with ICS and LABA were also given pranlukast (450 mg daily). Asthma-related symptoms, pulmonary function, blood eosinophil counts and several inflammatory markers in sputum were monitored at week 0, as well as at 4 and 8 weeks after starting therapy with pranlukast. RESULTS: Adding pranlukast did not further improve blood eosinophil counts, pulmonary function and symptoms, but significantly attenuated sputum cysteinyl leukotrienes, tumor necrosis factor-alpha and interleukin-5 concentrations. CONCLUSIONS: Although the clinical relevance remains obscure, adding an LTRA attenuates allergic airway inflammation in some asthmatics undergoing treatment with ICS and LABA.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Respiration, 76(4), pp.398-402; 2008", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Karger AG"}]}, "item_2_relation_11": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "18689991", "subitem_relation_type_select": "PMID"}}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1159/000151289", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright c 2008 S. Karger AG, Basel"}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00816840", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00257931", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1423-0356", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tomari, Shinya"}], "nameIdentifiers": [{"nameIdentifier": "63691", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuse, Hiroto"}], "nameIdentifiers": [{"nameIdentifier": "63692", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirose, Hiroko"}], "nameIdentifiers": [{"nameIdentifier": "63693", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuchida, Tomoko"}], "nameIdentifiers": [{"nameIdentifier": "63694", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukahori, Susumu"}], "nameIdentifiers": [{"nameIdentifier": "63695", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukushima, Chizu"}], "nameIdentifiers": [{"nameIdentifier": "63696", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawano, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "63697", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuo, Nobuko"}], "nameIdentifiers": [{"nameIdentifier": "63698", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kohno, Shigeru"}], "nameIdentifiers": [{"nameIdentifier": "63699", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Respiration76_398.pdf", "filesize": [{"value": "97.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 97700.0, "url": {"label": "Respiration76_398.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/16615/files/Respiration76_398.pdf"}, "version_id": "1af00cfa-d36d-4c94-bc63-5731fc3b9c73"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Additive therapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Airway inflammation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Asthma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Inhaled corticosteroid", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Leukotriene receptor antagonist", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Long-acting β2- agonist", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Observational study of the additive effects of pranlukast on inflammatory markers of clinically stable asthma with inhaled corticosteroids and long-acting beta 2 agonists.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Observational study of the additive effects of pranlukast on inflammatory markers of clinically stable asthma with inhaled corticosteroids and long-acting beta 2 agonists."}]}, "item_type_id": "2", "owner": "2", "path": ["30"], "permalink_uri": "http://hdl.handle.net/10069/22496", "pubdate": {"attribute_name": "公開日", "attribute_value": "2009-11-24"}, "publish_date": "2009-11-24", "publish_status": "0", "recid": "16615", "relation": {}, "relation_version_is_last": true, "title": ["Observational study of the additive effects of pranlukast on inflammatory markers of clinically stable asthma with inhaled corticosteroids and long-acting beta 2 agonists."], "weko_shared_id": -1}
Observational study of the additive effects of pranlukast on inflammatory markers of clinically stable asthma with inhaled corticosteroids and long-acting beta 2 agonists.
http://hdl.handle.net/10069/22496
http://hdl.handle.net/10069/224968bc99c8d-b6c5-4877-b96a-3e1af3debe22
名前 / ファイル | ライセンス | アクション |
---|---|---|
Respiration76_398.pdf (97.7 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2009-11-24 | |||||
タイトル | ||||||
タイトル | Observational study of the additive effects of pranlukast on inflammatory markers of clinically stable asthma with inhaled corticosteroids and long-acting beta 2 agonists. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Additive therapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Airway inflammation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Asthma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Inhaled corticosteroid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Leukotriene receptor antagonist | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Long-acting β2- agonist | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tomari, Shinya
× Tomari, Shinya× Matsuse, Hiroto× Hirose, Hiroko× Tsuchida, Tomoko× Fukahori, Susumu× Fukushima, Chizu× Kawano, Tetsuya× Matsuo, Nobuko× Kohno, Shigeru |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: Little is understood about the additive effects of leukotriene receptor antagonists (LTRA) on asthmatics currently medicated with inhaled corticosteroids (ICS) and long-acting beta(2)-agonists (LABA). OBJECTIVES: The present study examines the anti-inflammatory effects of the LTRA pranlukast in addition to ICS and LABA, among asthmatic patients with normal pulmonary function and unremarkable clinical symptoms. METHODS: Fifteen adult asthmatics participated in a 2-month, open-label, uncontrolled, prospective, multicenter, observational trial. Patients stabilized (predicted forced expiratory volume in 1 s >80%) by medication with ICS and LABA were also given pranlukast (450 mg daily). Asthma-related symptoms, pulmonary function, blood eosinophil counts and several inflammatory markers in sputum were monitored at week 0, as well as at 4 and 8 weeks after starting therapy with pranlukast. RESULTS: Adding pranlukast did not further improve blood eosinophil counts, pulmonary function and symptoms, but significantly attenuated sputum cysteinyl leukotrienes, tumor necrosis factor-alpha and interleukin-5 concentrations. CONCLUSIONS: Although the clinical relevance remains obscure, adding an LTRA attenuates allergic airway inflammation in some asthmatics undergoing treatment with ICS and LABA. | |||||
書誌情報 |
Respiration; international review of thoracic diseases 巻 76, 号 4, p. 398-402, 発行日 2008-11 |
|||||
出版者 | ||||||
出版者 | Karger AG | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00257931 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1423-0356 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00816840 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18689991 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1159/000151289 | |||||
権利 | ||||||
権利情報 | Copyright c 2008 S. Karger AG, Basel | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Respiration, 76(4), pp.398-402; 2008 |